{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have demonstrated that microRNA-1197 (miR-1197) is implicated in the progression of cancer. In non‐small cell lung cancer (NSCLC), for instance, researchers have evaluated the expression levels and underlying functional mechanisms of miR-1197, suggesting that it may influence tumor biology through currently underexplored oncogenic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn prostate cancer, miR-1197 has emerged as a tumor-promoting factor. Studies revealed that the circular RNA hsa_circ_0075542—downregulated in prostate tumor tissues—acts as a competing endogenous RNA by sponging miR-1197, thereby modulating the HOXC11 axis. Functional experiments in prostate cancer cell lines (LNCaP and PC3) demonstrated that overexpression of miR-1197 enhanced proliferation, migration, and invasiveness, while the circRNA mitigated these effects by sequestering miR-1197."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTogether, these findings highlight miR-1197 as a potential oncogenic modulator, whose aberrant expression may drive tumor progression in multiple cancer types. The opposing interplay between miR-1197 and its regulatory circRNA in prostate cancer not only underscores its functional significance but also suggests that targeting the miR-1197/HOXC11 axis might offer new therapeutic avenues in cancer management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bo Sun, Juan Hua, Hongwei Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1197 downregulation inhibits proliferation and migration in human non- small cell lung cancer cells by upregulating HOXC11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.109041"}], "href": "https://doi.org/10.1016/j.biopha.2019.109041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31181445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31181445"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuefu Han, Xingqiao Wen, Xiaojuan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA hsa_circ_0075542 acts as a sponge for microRNA-1197 to suppress malignant characteristics and promote apoptosis in prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1967064"}], "href": "https://doi.org/10.1080/21655979.2021.1967064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34515615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34515615"}]}]}]}