MIR1200 Gene

HGNC Family Non-coding RNAs
Name microRNA 1200
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn osteosarcoma, miR‐1200 is sequestered by the highly expressed circ‐0001785, which limits its availability to repress its downstream target HOXB2. The resulting up-regulation of HOXB2 activates the PI3K/Akt signaling cascade and modulates influences on apoptosis regulators, thereby promoting osteosarcoma cell proliferation and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn gastric cancer, a similar regulatory mechanism is observed. Here, the circular RNA circ_0026359 is overexpressed in tumor tissues and notably in cisplatin-resistant cells. circ_0026359 directly binds and negatively regulates miR‐1200, relieving its inhibitory effect on the target gene POLD4. The upregulation of POLD4 via the miR‐1200/POLD4 axis contributes to chemoresistance to cisplatin, thus underscoring the role of miR‐1200 in modulating drug response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in the context of gestational diabetes mellitus, the circular RNA circ_0074673 modulates endothelial cell function through a miR‐1200-dependent mechanism. By sponging miR‐1200 in high glucose–treated human umbilical vein endothelial cells, circ_0074673 indirectly facilitates the expression of MEOX2. This regulatory axis affects cellular proliferation, migration, and angiogenesis, suggesting that miR‐1200 plays a critical role in vascular dysfunction associated with gestational diabetes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shenglong Li, Yi Pei, Wei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA 0001785 regulates the pathogenesis of osteosarcoma as a ceRNA by sponging miR-1200 to upregulate HOXB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2019.1618127"}], "href": "https://doi.org/10.1080/15384101.2019.1618127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31116090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31116090"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zongyao Zhang, Xin Yu, Bo Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circ_0026359 Enhances Cisplatin Resistance in Gastric Cancer via Targeting miR-1200/POLD4 Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/5103272"}], "href": "https://doi.org/10.1155/2020/5103272"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32855967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32855967"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan Huang, Bo Liang, Xiangjuan Chen "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal circular RNA circ_0074673 regulates the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells via the microRNA-1200/MEOX2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1967077"}], "href": "https://doi.org/10.1080/21655979.2021.1967077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34516311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34516311"}]}]}]}
Synonyms HSA-MIR-1200, MIRN1200
NCBI Gene ID 100302113
API
Download Associations
Predicted Functions View MIR1200's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1200's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1200's ARCHS4 Predicted Functions.

Functional Associations

MIR1200 has 187 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR1200 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1200 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1200 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1200 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1200 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1200 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1200 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1200 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1200 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1200 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1200 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1200 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.