{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‑1202 is a primate‐specific microRNA that is highly enriched in the human brain and plays an important role in mood regulation. In individuals with major depressive disorder, aberrant expression of miR‑1202 has been shown to regulate the expression of metabotropic glutamate receptor‑4 (GRM4), thereby modulating neuronal signaling and predicting antidepressant response. These findings position miR‑1202 as both a molecular marker for depression and a potential target for novel antidepressant therapies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its involvement in depression, miR‑1202 functions as a tumor suppressor in several cancer settings. In glioma cells, reduced miR‑1202 expression leads to enhanced cell proliferation, whereas restoring its levels directly targets and suppresses Rab1A, triggering endoplasmic reticulum stress and apoptotic cell death. Similarly, in endometrial cancer, miR‑1202 expression correlates with the disease state, and experimental alterations—either by silencing miR‑1202 or by overexpressing complementary factors—result in increased apoptosis, G1 phase arrest, and diminished migratory as well as invasive abilities of cancer cells, underscoring its potential as a biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma, low miR‑1202 levels are associated with metastasis‐related clinical features and poorer overall and disease‐free survival rates. Mechanistic studies reveal that miR‑1202 exerts its antitumor effects by directly targeting cyclin-dependent kinase 14 (CDK14), thereby inhibiting cancer cell proliferation, migration, and invasion. These observations further highlight the multifaceted role of miR‑1202 as a regulator of tumor progression and as a promising candidate for targeted therapeutic strategies in liver cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Juan Pablo Lopez, Raymond Lim, Cristiana Cruceanu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MiR-1202 functions as a tumor suppressor in glioma cells by targeting Rab1A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1010428317697565"}], "href": "https://doi.org/10.1177/1010428317697565"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28443461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28443461"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hong Chen, Yujuan Fan, Wensheng Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exploration of miR-1202 and miR-196a in human endometrial cancer based on high throughout gene screening analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.5596"}], "href": "https://doi.org/10.3892/or.2017.5596"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28440476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28440476"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bo Du, Peng Zhang, Zhiming Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1202 suppresses hepatocellular carcinoma cells migration and invasion by targeting cyclin dependent kinase 14."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.11.090"}], "href": "https://doi.org/10.1016/j.biopha.2017.11.090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29217161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29217161"}]}]}]}