MIR1204 Gene

HGNC Family Non-coding RNAs
Name microRNA 1204
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR-1204, a microRNA embedded within the large non-coding PVT1 locus, plays versatile roles in cancer biology. Initially, it was shown that p53, a key tumor suppressor, directly binds to and activates regulatory elements within the PVT1 locus, thereby upregulating miR-1204 among other non-coding RNAs. Notably, ectopic miR-1204 expression was found to elevate p53 levels and trigger cell death in a partially p53-dependent manner, suggesting the existence of a regulatory feedback loop linking p53 activity and miR-1204 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSubsequent investigations have uncovered multiple oncogenic roles for miR-1204 depending on the tumor context. In nasopharyngeal carcinoma, miR-1204 is notably downregulated in paclitaxel-resistant cells, and its restoration re-sensitizes these cells to chemotherapy while inhibiting tumor growth, indicating its potential utility in overcoming drug resistance. In breast cancer, increased miR-1204 expression correlates with poor prognosis; it drives proliferation, epithelial-mesenchymal transition, and invasion by targeting the vitamin D receptor (VDR). Similarly, in ovarian squamous cell carcinoma, miR-1204 overexpression promotes tumor growth by upregulating GLUT-1 expression and enhancing glucose uptake. In non-small-cell lung cancer, elevated miR-1204 levels contribute to enhanced cell proliferation through downregulation of the tumor suppressor PITX1, and additional studies are investigating its influence on DEK oncogene expression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, the role of miR-1204 in colorectal cancer remains to be clarified, despite its presence in the PVT1 locus which has been implicated in diverse tumorigenic processes. Future studies are needed to elucidate whether miR-1204 contributes to colorectal carcinogenesis and to determine its potential as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anthony M Barsotti, Rachel Beckerman, Oleg Laptenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53-Dependent induction of PVT1 and miR-1204."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.322875"}], "href": "https://doi.org/10.1074/jbc.M111.322875"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22110125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22110125"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaowei Peng, Peiguo Cao, Jingjing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1204 sensitizes nasopharyngeal carcinoma cells to paclitaxel both in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2014.1001287"}], "href": "https://doi.org/10.1080/15384047.2014.1001287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25756509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25756509"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoyan Liu, Lei Bi, Qin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1204 targets VDR to promotes epithelial-mesenchymal transition and metastasis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0215-2"}], "href": "https://doi.org/10.1038/s41388-018-0215-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29555976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29555976"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jia Xu, XiaoLi Gu, Xiaozhuo Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1204 promotes ovarian squamous cell carcinoma growth by increasing glucose uptake."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Biotechnol Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09168451.2018.1527208"}], "href": "https://doi.org/10.1080/09168451.2018.1527208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30304996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30304996"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wei Jiang, Yaozhou He, Yijun Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1204 promotes cell proliferation by regulating PITX1 in non-small-cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.11083"}], "href": "https://doi.org/10.1002/cbin.11083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30549141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30549141"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhen Qian, Juan Yang, Huanhuan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-1204 regulates apoptosis in NSCLC cells by targeting DEK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Folia Histochem Cytobiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5603/FHC.a2019.0009"}], "href": "https://doi.org/10.5603/FHC.a2019.0009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31246264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31246264"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Simeng Tian, Meilin Chen, Wanting Jing, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "miR-1204"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Positioning in 8q24.21 Involved in the Tumorigenesis of Colorectal Cancer by Targeting "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MASPIN"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Pept Lett (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/0109298665305114240718072029"}], "href": "https://doi.org/10.2174/0109298665305114240718072029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39082173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39082173"}]}]}]}
Synonyms HSA-MIR-1204
NCBI Gene ID 100302185
API
Download Associations
Predicted Functions View MIR1204's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1204's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1204's ARCHS4 Predicted Functions.

Functional Associations

MIR1204 has 1,212 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR1204 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1204 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1204 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1204 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1204 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1204 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1204 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1204 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR1204 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1204 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1204 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR1204 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR1204 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1204 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1204 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.