{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAccumulating evidence indicates that miR‑1205 is a multifunctional microRNA whose regulatory roles in cancer are mediated in part through its interactions with circular RNAs. In glioma and papillary thyroid cancer, for instance, specific circRNAs (such as circ_0034642, hsa_circ_0034642, hsa_circ_0039411, and circRASSF2) act as sponges for miR‑1205. This sequestration leads to de‐repression of key oncogenic targets—BATF3 in glioma, MTA1 and ABCA9 in papillary thyroid cancer, and HOXA1 in breast cancer—thereby promoting cell proliferation, migration, invasion, and resistance to apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn other tumor contexts, miR‑1205 exhibits context‑dependent functions. In castration‑resistant prostate cancer, increased copy number and expression of miR‑1205 promote cell proliferation and cell cycle progression by directly targeting EGLN3. Moreover, in lung adenocarcinoma, a novel miR‑1205 was identified, suggesting its potential involvement in tumorigenesis. In hepatocellular carcinoma (HCC), miR‑1205 overexpression suppresses cell proliferation via direct interaction with CSNK2B, thereby interfering with the downstream CDK4/pRb pathway."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDistinct roles have also been reported in cancers of the head and breast. In laryngeal squamous cell carcinoma, miR‑1205 is significantly downregulated, and its enforced expression inhibits migration, growth, and invasion—effects attributable to its targeting of the transcription factor E2F1, which itself can suppress miR‑1205 expression through a feedback loop. Conversely, in breast cancer, miR‑1205 is upregulated in metastatic tumors and promotes invasiveness and metastasis by directly targeting CDK3, ultimately modulating Snail degradation and facilitating epithelial‑to‑mesenchymal transition. These findings underscore the context‑dependent and multifaceted roles of miR‑1205 across different tumor types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mengli Yang, Gang Li, Lujia Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circ_0034642 elevates BATF3 expression and promotes cell proliferation and invasion through miR-1205 in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.12.052"}], "href": "https://doi.org/10.1016/j.bbrc.2018.12.052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30551880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30551880"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chao Yi, Hongbin Li, Dan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of circular RNA circ_0034642 indicates unfavorable prognosis in glioma and facilitates cell proliferation and invasion via the miR-1205/BATF3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28646"}], "href": "https://doi.org/10.1002/jcb.28646"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30938850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30938850"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yimin Yang, Lili Ding, Yanhua Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0039411 promotes tumorigenesis and progression of papillary thyroid cancer by miR-1179/ABCA9 and miR-1205/MTA1 signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29048"}], "href": "https://doi.org/10.1002/jcp.29048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31270819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31270819"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wei Zhong, Lei Bao, Yangyi Yuan, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "microRNA-1205 promotes cell growth by targeting APC2 in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201902_17003"}], "href": "https://doi.org/10.26355/eurrev_201902_17003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30779081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30779081"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yicun Wang, Xin Li, Wei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1205, encoded on chromosome 8q24, targets EGLN3 to induce cell growth and contributes to risk of castration-resistant prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-019-0760-3"}], "href": "https://doi.org/10.1038/s41388-019-0760-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30808975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30808975"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiang Li, Shujie Xie, Qin Xia, et al. 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