MIR1206 Gene

HGNC Family Non-coding RNAs
Name microRNA 1206
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR-1206 is a microRNA located within the multi-cancer susceptibility region 8q24.2, where functional studies have revealed that genetic variations within its precursor transcript—such as a common single nucleotide polymorphism (SNP)—can affect its biogenesis. Notably, while variations in other microRNAs like miR-612 exhibit cell type–specific effects on mature miRNA expression, the SNP in miR-1206 appears to modulate its processing in a consistent manner across different cell types. This suggests that changes in miR-1206 maturation could influence gene regulatory networks relevant to tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in cancer biology, genetic variation in miR-1206 has also been linked to drug-induced toxicity in clinical settings. In pediatric acute lymphoblastic leukemia, for instance, a specific SNP in miR-1206 (rs2114358) has been associated with a significantly increased risk of methotrexate-induced oral mucositis. These findings point to the potential utility of miR-1206 genetic variants as predictive biomarkers for treatment-related adverse effects, paving the way for more personalized therapeutic strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, association studies have begun to implicate polymorphisms in miR-1206 in the predisposition to hematological malignancies such as chronic myeloid leukemia. Although further investigations are needed to fully delineate the target genes and downstream pathways regulated by miR-1206, current evidence underscores its functional relevance in both cancer susceptibility and treatment response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hye Kyung Kim, Ludmila Prokunina-Olsson, Stephen J Chanock "}, {"type": "b", "children": [{"type": "t", "text": "Common genetic variants in miR-1206 (8q24.2) and miR-612 (11q13.3) affect biogenesis of mature miRNA forms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0047454"}], "href": "https://doi.org/10.1371/journal.pone.0047454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23077621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23077621"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Angela Gutierrez-Camino, Natanja Oosterom, Marissa A H den Hoed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-1206 microRNA variant is associated with methotrexate-induced oral mucositis in pediatric acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FPC.0000000000000291"}], "href": "https://doi.org/10.1097/FPC.0000000000000291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28628559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28628559"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Fathelrahman Mahdi Hassan "}, {"type": "b", "children": [{"type": "t", "text": "The Association of rs2114358 in the miR-1206 Polymorphism to Chronic Myeloid Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microrna (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/2211536608666190102143439"}], "href": "https://doi.org/10.2174/2211536608666190102143439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30605069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30605069"}]}]}]}
Synonyms HSA-MIR-1206, MIRN1206
NCBI Gene ID 100302170
API
Download Associations
Predicted Functions View MIR1206's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1206's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1206's ARCHS4 Predicted Functions.

Functional Associations

MIR1206 has 340 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR1206 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1206 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1206 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1206 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1206 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1206 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1206 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1206 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR1206 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR1206 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1206 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1206 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR1206 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1206 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1206 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.