{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐1208 (miR-1208) has emerged as a multifunctional regulatory molecule with diverse roles in disease. In renal cancer cells, ectopic expression of miR-1208 leads to apoptotic cell death—demonstrated by the accumulation of sub-G1 populations and the cleavage of procaspase-3 and PARP—by directly binding to the 3′-untranslated region of TBC1 domain containing kinase (TBCK) mRNA, thereby repressing TBCK expression; this suppression not only suggests a tumor suppressor role for miR-1208 but also increases the cells’ sensitivity to chemotherapeutic agents such as cisplatin and TRAIL."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate context, within atherosclerosis, the long noncoding RNA HAND2-AS1 has been shown to target the miR-1208/SIRT1 axis, where the modulation of miR-1208 is linked to enhanced SIRT1 expression and the promotion of cholesterol efflux proteins ABCA1/G1, collectively contributing to the alleviation of foam cell formation—a critical event in plaque development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, genetic studies investigating gene polymorphisms indicate that variations in MIR1208 may influence susceptibility to chronic obstructive pulmonary disease (COPD), further underscoring the potential clinical relevance of miR-1208 in complex human disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Eun-Ae Kim, Ji-Hoon Jang, Eon-Gi Sung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1208 Increases the Sensitivity to Cisplatin by Targeting TBCK in Renal Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms20143540"}], "href": "https://doi.org/10.3390/ijms20143540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31331056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31331056"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lingyun Ma, Shigui He, Helan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HAND2-AS1 targeting miR-1208/SIRT1 axis alleviates foam cell formation in atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cardiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijcard.2021.11.019"}], "href": "https://doi.org/10.1016/j.ijcard.2021.11.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34780888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34780888"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Y Zhou, F Bai, X Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms in MIR1208 and MIR5708 are associated with susceptibility to COPD in the Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pulmonology (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pulmoe.2021.07.004"}], "href": "https://doi.org/10.1016/j.pulmoe.2021.07.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36115827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36115827"}]}]}]}