MIR1226 Gene

HGNC Family Non-coding RNAs
Name microRNA 1226
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‐1226 has emerged as a critical tumor suppressor in the context of breast cancer. In particular, one study showed that miR‐1226 binds to a conserved motif in the 3′UTR of the MUC1 mRNA, thereby downregulating the MUC1 oncoprotein. This downregulation is associated with increased reactive oxygen species levels, loss of mitochondrial membrane potential, and decreased cell survival, collectively supporting its tumor‐suppressive role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Furthermore, within a broader investigation of noncoding RNAs in invasive breast cancer, the complex regulatory environment that includes miR‐1226 was highlighted."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In addition, another study provided evidence that miR‐1226-3p directly targets key components of the PI3K/AKT signaling pathway—namely HER2, PIK3R2, and AKT1—leading to a reduction in cellular proliferation and promotion of apoptosis in specific breast cancer models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its oncogenic implications, miR‐1226 has also been examined in the context of periodontal disease. A pilot study first described an effective procedure for purifying miRNAs from gingival crevicular fluid in patients with chronic periodontitis, establishing a baseline for quantitatively assessing miRNA expression in oral inflammatory conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Complementing this methodological advance, another study reported that miR‐1226 is dysregulated in periodontitis, thereby suggesting that its altered expression may be functionally significant and lend support to its potential utility as a biomarker in periodontal disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMiR‐1226’s regulatory impact is not restricted to breast cancer and periodontitis. Emerging evidence also points to its relevance in non‐small cell lung cancer, where altered expression levels of miR‐1226 in tissue samples and cell lines have been associated with malignant progression. These findings further emphasize the importance of miR‐1226 as a multifunctional regulator across diverse disease contexts, opening avenues for its potential clinical application both as a therapeutic target and as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Caining Jin, Hasan Rajabi, Donald Kufe "}, {"type": "b", "children": [{"type": "t", "text": "miR-1226 targets expression of the mucin 1 oncoprotein and induces cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo_00000653"}], "href": "https://doi.org/10.3892/ijo_00000653"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20514397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20514397"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiao-Yu Li, Li-Ye Zhou, Hao Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long noncoding RNA MIR210HG promotes tumor metastasis by acting as a ceRNA of miR-1226-3p to regulate mucin-1c expression in invasive breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102149"}], "href": "https://doi.org/10.18632/aging.102149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31399552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31399552"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zahra Mohamadzade, Bahram M Soltani, Zahra Ghaemi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell specific tumor suppressor effect of Hsa-miR-1226-3p through downregulation of HER2, PIK3R2, and AKT1 genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2021.105965"}], "href": "https://doi.org/10.1016/j.biocel.2021.105965"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33675995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33675995"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "P Micó-Martínez, J-L García-Giménez, M Seco-Cervera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1226 detection in GCF as potential biomarker of chronic periodontitis: A pilot study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oral Patol Oral Cir Bucal (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4317/medoral.22329"}], "href": "https://doi.org/10.4317/medoral.22329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29680855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29680855"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yimin Du, Yue-Sun Qi, Hui Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression and clinical significance of miR-1226 in patients with periodontitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Oral Health (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12903-021-01855-y"}], "href": "https://doi.org/10.1186/s12903-021-01855-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34592963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34592963"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Feng Lin, Runsheng Li "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1226, mediated by ASCL1, suppresses the progression of non-small cell lung cancer by targeting FGF2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bull Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bulcan.2021.11.017"}], "href": "https://doi.org/10.1016/j.bulcan.2021.11.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35164915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35164915"}]}]}]}
Synonyms MIRN1226, MIR-1226, HSA-MIR-1226
NCBI Gene ID 100302232
API
Download Associations
Predicted Functions View MIR1226's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1226's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1226's ARCHS4 Predicted Functions.

Functional Associations

MIR1226 has 744 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.

Click the + buttons to view associations for MIR1226 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1226 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1226 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1226 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1226 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1226 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1226 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1226 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR1226 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR1226 from the GeneSigDB Published Gene Signatures dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1226 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR1226 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1226 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1226 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.