| HGNC Family | Non-coding RNAs |
| Name | microRNA 1234 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations indicate that miR‑1234 plays a regulatory role in lymphoma by modulating key signaling pathways. In diffuse large B‑cell lymphoma (DLBCL) of the activated B‑cell type, miR‑1234 was found to be significantly up‑regulated in patient tissues from regions with distinct environmental exposures. Its expression level was inversely correlated with STAT3 protein levels, and functional studies demonstrated that transfection of miR‑1234 resulted in the down‑regulation of STAT3. This suggests that miR‑1234 may act to temper STAT3‑mediated pro‑survival and inflammatory signaling pathways potentially contributing to lymphoma tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn gastric cancer, miR‑1234 is similarly implicated in tumorigenesis via its involvement in a regulatory axis with the circular RNA hsa_circ_0006470 and the tumor suppressor TP53I11. Overexpression of hsa_circ_0006470 inhibited cell viability, proliferation, and migration by effectively sponging miR‑1234, which in turn prohibited miR‑1234 from repressing TP53I11 expression. This interplay reveals that the miR‑1234/TP53I11 axis is a critical mediator in the progression of gastric cancer, providing potential avenues for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Therese Högfeldt, Per Johnsson, Dan Grandér, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Lymphoma (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/10428194.2013.824077"}], "href": "https://doi.org/10.3109/10428194.2013.824077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23841503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23841503"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jinbi Xie, Yong Ning, Lihang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of hsa_circ_0006470 inhibits the malignant behavior of gastric cancer cells <em>via</em> regulation of miR-1234/TP53I11 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Histochem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4081/ejh.2022.3477"}], "href": "https://doi.org/10.4081/ejh.2022.3477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36190397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36190397"}]}]}]}
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| Synonyms | HSA-MIR-1234, MIRN1234 |
| NCBI Gene ID | 100302196 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR1234 has 375 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.
Click the + buttons to view associations for MIR1234 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR1234 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1234 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of MIR1234 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR1234 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR1234 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1234 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIR1234 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with MIR1234 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MIR1234 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR1234 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of MIR1234 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR1234 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| WikiPathways Pathways 2014 | pathways involving MIR1234 protein from the Wikipathways Pathways 2014 dataset. | |
