MIR124-3 Gene

HGNC Family Non-coding RNAs
Name microRNA 124-3
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐124‐3p has emerged as a pivotal tumor suppressor in a wide array of human malignancies. In hepatocellular, pancreatic, colorectal, nasopharyngeal, cervical, oral, bladder, gastric, breast, prostate, lung, renal, gallbladder, tongue, and brain cancers, miR‐124‐3p is frequently down‐regulated—often through promoter hypermethylation or sequestration within competing endogenous RNA networks—which in turn releases its multiple oncogenic targets from repression. Functional studies demonstrate that restoration of miR‐124‐3p inhibits cell proliferation, migration, invasion, and even overcomes chemoresistance by directly targeting tumor‐promoting effectors such as cyclin‐dependent kinase 6, integrin β1, Rac1, PTB1, DNMT3B, PIM1, androgen receptor, SOX9, and key components of the PI3K/Akt, NF‑κB, and TGF‑β signaling pathways. Moreover, miR‐124‐3p activity is intricately modulated by noncoding RNAs—including circular RNAs (e.g., circHIPK3) and long noncoding RNAs (e.g., UCA1, NEAT1, OGFRP1)—which sponge this miRNA to impair its tumor‐suppressive function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "38"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in oncogenesis, miR‐124‐3p serves as an important regulator in various non‐malignant settings. It modulates innate immune responses by fine‐tuning toll‐like receptor signaling during mycobacterial infection and orchestrates inflammatory cascades. Within the vasculature, miR‐124‐3p governs the phenotypic switch and proliferation of vascular smooth muscle cells, thereby contributing to the pathogenesis of atherosclerosis, aortic dissection, and diabetes‐related vascular dysfunction. In the central nervous system, aberrant miR‐124‐3p expression is associated with traumatic brain injury and can serve as a diagnostic indicator for acute stroke and a marker for disease progression in amyotrophic lateral sclerosis. Furthermore, in cardiomyocytes its dysregulation—often influenced by circular RNA interactions—can exacerbate ischemia/reperfusion injury."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "39", "end_ref": "45"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mayuko Furuta, Ken-ich Kozaki, Shinji Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgp250"}], "href": "https://doi.org/10.1093/carcin/bgp250"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19843643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19843643"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Stuart Hunt, Adam V Jones, Emma E Hinsley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2010.11.038"}], "href": "https://doi.org/10.1016/j.febslet.2010.11.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21112327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21112327"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "K Gebauer, I Peters, N Dubrowinskaja, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/bjc.2012.537"}], "href": "https://doi.org/10.1038/bjc.2012.537"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23321515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23321515"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "P Wang, L Chen, J Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.598"}], "href": "https://doi.org/10.1038/onc.2012.598"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23334332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23334332"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xianglai Xu, Shiqi Li, Yiwei Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1479-5876-11-276"}], "href": "https://doi.org/10.1186/1479-5876-11-276"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24180482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24180482"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Riadh Ben Gacem, Olfa Ben Abdelkrim, Sonia Ziadi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation of miR-124a-1, miR-124a-2, and miR-124a-3 genes correlates with aggressive and advanced breast cancer disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-013-1530-4"}], "href": "https://doi.org/10.1007/s13277-013-1530-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24375250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24375250"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hailong Li, Shoupin Xie, Min Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The clinical significance of downregulation of mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p in gastric cancer tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2014.2415"}], "href": "https://doi.org/10.3892/ijo.2014.2415"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24805774"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24805774"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiao Hong Peng, Hao Ran Huang, Juan Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-124 suppresses tumor growth and metastasis by targeting Foxq1 in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-13-186"}], "href": "https://doi.org/10.1186/1476-4598-13-186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25098939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25098939"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hai-Ying Wan, Qin-Qin Li, Yan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-124 represses vasculogenic mimicry and cell motility by targeting amotL1 in cervical cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2014.09.005"}], "href": "https://doi.org/10.1016/j.canlet.2014.09.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25218344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25218344"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kohei Taniguchi, Nobuhiko Sugito, Minami Kumazaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2015.03.026"}], "href": "https://doi.org/10.1016/j.canlet.2015.03.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25818238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25818238"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Liang-Liang Dong, Li-Ming Chen, Wei-Min Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of microRNA-124 is an independent unfavorable prognostic factor for patients with breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diagn Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13000-015-0257-5"}], "href": "https://doi.org/10.1186/s13000-015-0257-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25924779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25924779"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Henriett Butz, Peter M Szabó, Heba W Z Khella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-target network reveals miR-124as a key miRNA contributing to clear cell renal cell carcinoma aggressive behaviour by targeting CAV1 and FLOT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3815"}], "href": "https://doi.org/10.18632/oncotarget.3815"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26002553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26002553"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xinsheng Wang, Qiaoli Wu, Bin Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-124 exerts tumor suppressive functions on the cell proliferation, motility and angiogenesis of bladder cancer by fine-tuning UHRF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.13502"}], "href": "https://doi.org/10.1111/febs.13502"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26310391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26310391"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Zhiheng Chen, Shaojun Liu, Li Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.5709"}], "href": "https://doi.org/10.18632/oncotarget.5709"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26497367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26497367"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xu-Bao Shi, Ai-Hong Ma, Lingru Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-0795"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-0795"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26573802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26573802"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Lidong Zu, Yunjing Xue, Jinglong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The feedback loop between miR-124 and TGF-β pathway plays a significant role in non-small cell lung cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgw011"}], "href": "https://doi.org/10.1093/carcin/bgw011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26818357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26818357"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xiaoying Wang, Yanli Liu, Xiaoli Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-124 inhibits cell proliferation, migration and invasion by directly targeting SOX9 in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.4648"}], "href": "https://doi.org/10.3892/or.2016.4648"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26935152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26935152"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Danni Deng, Lei Wang, Yao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-124-3p regulates cell proliferation, invasion, apoptosis, and bioenergetics by targeting PIM1 in astrocytoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.12946"}], "href": "https://doi.org/10.1111/cas.12946"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27088547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27088547"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Young Hun Kim, Won Kee Lee, Eung Bae Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combined Effect of Metastasis-Related MicroRNA, miR-34 and miR-124 Family, Methylation on Prognosis of Non-Small-Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lung Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cllc.2016.06.005"}], "href": "https://doi.org/10.1016/j.cllc.2016.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27444357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27444357"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Fengfeng Zhang, Binbin Wang, Houlong Long, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased miR-124-3p Expression Prompted Breast Cancer Cell Progression Mainly by Targeting Beclin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7754/clin.lab.2015.151111"}], "href": "https://doi.org/10.7754/clin.lab.2015.151111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27468577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27468577"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Yanbo Wang, Luxiao Chen, Zhenyu Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-124-3p functions as a tumor suppressor in breast cancer by targeting CBL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-016-2862-4"}], "href": "https://doi.org/10.1186/s12885-016-2862-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27842510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27842510"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Wanchen Qiao, Beisong Guo, Haichun Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-124 suppresses glioblastoma growth and potentiates chemosensitivity by inhibiting AURKA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.02.120"}], "href": "https://doi.org/10.1016/j.bbrc.2017.02.120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28242198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28242198"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "A Valentino, A Calarco, A Di Salle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deregulation of MicroRNAs mediated control of carnitine cycle in prostate cancer: molecular basis and pathophysiological consequences."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2017.216"}], "href": "https://doi.org/10.1038/onc.2017.216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28671672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28671672"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Mengjie Wang, Bi Meng, Yangchen Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-124 Inhibits Growth and Enhances Radiation-Induced Apoptosis in Non-Small Cell Lung Cancer by Inhibiting STAT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000485907"}], "href": "https://doi.org/10.1159/000485907"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29237164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29237164"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Shuai Xiao, Rensheng Wang, Xiangwei Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Long Noncoding RNA TP73-AS1 Interacted with miR-124 to Modulate Glioma Growth by Targeting Inhibitor of Apoptosis-Stimulating Protein of p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2017.3941"}], "href": "https://doi.org/10.1089/dna.2017.3941"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29412778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29412778"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Guilong Zhang, Lukui Chen, Ahsan Ali Khan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-124-3p/neuropilin-1(NRP-1) axis plays an important role in mediating glioblastoma growth and angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.31329"}], "href": "https://doi.org/10.1002/ijc.31329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29457830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29457830"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Rabah B Zo, Ziwen Long "}, {"type": "b", "children": [{"type": "t", "text": "MiR-124-3p suppresses bladder cancer by targeting DNA methyltransferase 3B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.26591"}], "href": "https://doi.org/10.1002/jcp.26591"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29893409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29893409"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Ding Kai, Liao Yannian, Chen Yitian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA HIPK3 promotes gallbladder cancer cell growth by sponging microRNA-124."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.06.088"}], "href": "https://doi.org/10.1016/j.bbrc.2018.06.088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29928876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29928876"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Niina Vuokila, Katarzyna Lukasiuk, Anna Maria Bot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-124-3p is a chronic regulator of gene expression after brain injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-018-2911-z"}], "href": "https://doi.org/10.1007/s00018-018-2911-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30155647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30155647"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Li-Xin Tang, Guo-Hua Chen, Huan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA OGFRP1 regulates LYPD3 expression by sponging miR-124-3p and promotes non-small cell lung cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.09.146"}], "href": "https://doi.org/10.1016/j.bbrc.2018.09.146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30274775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30274775"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Hui-Deng Long, Yu-Shui Ma, Hui-Qiong Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced hsa-miR-124-3p levels are associated with the poor survival of patients with hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-018-4431-1"}], "href": "https://doi.org/10.1007/s11033-018-4431-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30341691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30341691"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Bo He, Feng Peng, Wei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of lncRNA-MALAT1 and miR-124 regulates HBx-induced cancer stem cell properties in HepG2 through PI3K/Akt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26823"}], "href": "https://doi.org/10.1002/jcb.26823"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30500989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30500989"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Jin-Rong Wang, Bin Liu, Lei Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-124-3p suppresses cell migration and invasion by targeting ITGA3 signaling in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-182000"}], "href": "https://doi.org/10.3233/CBM-182000"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30614803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30614803"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Tong-Han Zhang, Li-Zhong Liang, Xiao-Ling Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA UCA1/miR-124 axis modulates TGFβ1-induced epithelial-mesenchymal transition and invasion of tongue cancer cells through JAG1/Notch signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28334"}], "href": "https://doi.org/10.1002/jcb.28334"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30635938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30635938"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Dapeng Wang, Hongyang Xu, Bo Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA MALAT1 sponges miR‑124‑3p.1/KLF5 to promote pulmonary vascular remodeling and cell cycle progression of pulmonary artery hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2019.4256"}], "href": "https://doi.org/10.3892/ijmm.2019.4256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31257528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31257528"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Cong Liu, Hua Xing, Caixia Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-124 reversed the doxorubicin resistance of breast cancer stem cells through STAT3/HIF-1 signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2019.1638182"}], "href": "https://doi.org/10.1080/15384101.2019.1638182"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31286834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31286834"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Yamei Pang, Jie Wu, Xiang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEAT1/miR‑124/STAT3 feedback loop promotes breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2019.4841"}], "href": "https://doi.org/10.3892/ijo.2019.4841"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31322202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31322202"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Xinqi Jia, Xu Wang, Xiaorong Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-124: An emerging therapeutic target in cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2489"}], "href": "https://doi.org/10.1002/cam4.2489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31389160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31389160"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Ling Yan Leung, Cangel Pui Yee Chan, Yuk Ki Leung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Chim Acta (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cca.2014.03.007"}], "href": "https://doi.org/10.1016/j.cca.2014.03.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24650689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24650689"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Chunyan Ma, Yong Li, Min Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-124 negatively regulates TLR signaling in alveolar macrophages in response to mycobacterial infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2014.06.014"}], "href": "https://doi.org/10.1016/j.molimm.2014.06.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24995397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24995397"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Yangfeng Tang, Shangyi Yu, Yang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-124 controls human vascular smooth muscle cell phenotypic switch via Sp1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.00660.2016"}], "href": "https://doi.org/10.1152/ajpheart.00660.2016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28667053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28667053"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Junjiang Chen, Lianqun Cui, Jingliang Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA WDR77 target FGF-2 to regulate vascular smooth muscle cells proliferation and migration by sponging miR-124."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.10.068"}], "href": "https://doi.org/10.1016/j.bbrc.2017.10.068"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29042195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29042195"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "De-Hai Wu, Hao Liang, Shou-Nan Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-124 Suppresses Pancreatic Ductal Adenocarcinoma Growth by Regulating Monocarboxylate Transporter 1-Mediated Cancer Lactate Metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000494477"}], "href": "https://doi.org/10.1159/000494477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30355947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30355947"}]}, {"type": "r", "ref": 44, "children": [{"type": "t", "text": "M Bai, C-L Pan, G-X Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircHIPK3 aggravates myocardial ischemia-reperfusion injury by binding to miRNA-124-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201911_19580"}], "href": "https://doi.org/10.26355/eurrev_201911_19580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31799682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31799682"}]}, {"type": "r", "ref": 45, "children": [{"type": "t", "text": "Julia Yelick, Yuqin Men, Shijie Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated exosomal secretion of miR-124-3p from spinal neurons positively associates with disease severity in ALS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Neurol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.expneurol.2020.113414"}], "href": "https://doi.org/10.1016/j.expneurol.2020.113414"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32712030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32712030"}]}]}]}
Synonyms MIRN124-3, MIRN124A3, MIR-124-3
NCBI Gene ID 406909
API
Download Associations
Predicted Functions View MIR124-3's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR124-3's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR124-3's ARCHS4 Predicted Functions.

Functional Associations

MIR124-3 has 940 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR124-3 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR124-3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR124-3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR124-3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR124-3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR124-3 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR124-3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR124-3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR124-3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR124-3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR124-3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR124-3 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by MIR124-3 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR124-3 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR124-3 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
WikiPathways Pathways 2014 pathways involving MIR124-3 protein from the Wikipathways Pathways 2014 dataset.