MIR1243 Gene

HGNC Family Non-coding RNAs
Name microRNA 1243
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn pancreatic cancer, miR-1243 has been identified as an epithelial‐mesenchymal transition (EMT)–suppressive microRNA. Overexpression of miR-1243 promotes the expression of E-cadherin by repressing key EMT-associated genes, which not only helps prevent metastatic progression but also increases the sensitivity to the chemotherapeutic agent gemcitabine. These findings highlight the potential of miR-1243 as a therapeutic target and biomarker in pancreatic cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn tongue squamous cell carcinoma (TSCC), a distinct regulatory role for miR-1243 has emerged. Here, the circular RNA circ_0043265 functions as a competing endogenous RNA (ceRNA) by sponging miR-1243, thereby relieving its inhibitory effect on the transcription factor SALL1. The suppression of SALL1 by miR-1243 appears to promote cell proliferation, migration, and invasion; conversely, circ_0043265 overexpression mitigates these oncogenic effects, suggesting that miR-1243 contributes to tumor progression in TSCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies underscore the context-dependent functions of miR-1243 in cancer biology. In pancreatic cancer, miR-1243’s suppression of EMT aligns with a tumor-suppressive role, whereas in TSCC its activity—when left unsequestered by circ_0043265—may drive oncogenic processes via downregulation of SALL1. These insights into miR-1243’s dualistic regulatory mechanisms illustrate the complexity of microRNA-mediated control in diverse tumor microenvironments."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hidekazu Hiramoto, Tomoki Muramatsu, Daisuke Ichikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-509-5p and miR-1243 increase the sensitivity to gemcitabine by inhibiting epithelial-mesenchymal transition in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-04191-w"}], "href": "https://doi.org/10.1038/s41598-017-04191-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28638102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28638102"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cuijuan Qian, Yisheng Yang, Tianchen Lan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Oncol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/pore.2021.587130"}], "href": "https://doi.org/10.3389/pore.2021.587130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34257535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34257535"}]}]}]}
Synonyms MIRN1243, HSA-MIR-1243
NCBI Gene ID 100302188
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Predicted Functions View MIR1243's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1243's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1243's ARCHS4 Predicted Functions.

Functional Associations

MIR1243 has 362 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR1243 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1243 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1243 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1243 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1243 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1243 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1243 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1243 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1243 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1243 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1243 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1243 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.