MIR1244-1 Gene

HGNC Family Non-coding RNAs
Name microRNA 1244-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn cisplatin‐treated non–small cell lung cancer cells, reduced expression of miR‑1244 is associated with chemoresistance and poorer overall survival. Restoration of miR‑1244 levels suppresses cell viability, promotes caspase‑3 activity, and upregulates apoptotic mediators (p53 and Bax), while downregulating proliferative factors such as MEF2D and cyclin D1. Together, these findings indicate that miR‑1244 functions as a tumor suppressor by enhancing chemosensitivity and promoting apoptosis in lung cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn osteosarcoma, a circRNA—circSAMD4—has been shown to be highly expressed in tumor tissues relative to adjacent non‐cancerous tissues. This circRNA exerts its oncogenic effect by sponging miR‑1244, thereby relieving its inhibitory control on the MDM2 oncogene. The circSAMD4/miR‑1244/MDM2 regulatory loop promotes cell proliferation and enhances stemness features in osteosarcoma cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn ovarian cancer, miR‑1244 activity is similarly subverted by non‑coding RNAs. LINC00504, a long non‑coding RNA, acts as an endogenous sponge to downregulate miR‑1244, consequently facilitating increased cell proliferation, reduced apoptosis, and a metabolic shift toward aerobic glycolysis via modulation of key glycolytic enzymes (PKM2, HK2, and PDK1). In parallel, the circular RNA circ_0002711 sequesters miR‑1244 to relieve its suppression on ROCK1, further promoting tumor growth and the Warburg effect. Together, these studies underscore the importance of miR‑1244 as a critical mediator of ovarian cancer progression, with its inhibition by sponging RNAs contributing to enhanced tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, the stability of miR‑1244 is subject to regulation by RNA‑binding proteins. Specifically, depletion of RBM4 accelerates degradation of primary miR‑1244 transcripts, leading to lower mature miR‑1244 levels. This downregulation lifts miR‑1244‑mediated suppression of SERPINE1, thereby inducing cellular senescence in lung cancer cells and curtailing cancer progression. This mechanism highlights an additional layer of regulation where impaired miR‑1244 biogenesis contributes to tumor biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guang-Jian Li, Guang-Qiang Zhao, Jia-Peng Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of miR-1244 on cisplatin-treated non-small cell lung cancer via MEF2D expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.5624"}], "href": "https://doi.org/10.3892/or.2017.5624"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28498474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28498474"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhao Yanbin, Zhang Jing "}, {"type": "b", "children": [{"type": "t", "text": "CircSAMD4A accelerates cell proliferation of osteosarcoma by sponging miR-1244 and regulating MDM2 mRNA expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.05.182"}], "href": "https://doi.org/10.1016/j.bbrc.2019.05.182"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31200957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31200957"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ya Liu, Xiaocui He, Yuli Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00504 regulates the Warburg effect in ovarian cancer through inhibition of miR-1244."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-019-03647-z"}], "href": "https://doi.org/10.1007/s11010-019-03647-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31691157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31691157"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Weiquan Xie, L U Liu, Chuanyong He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0002711 knockdown suppresses cell growth and aerobic glycolysis by modulating miR-1244/ROCK1 axis in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biosci (2021)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33737494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33737494"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Luning Wang, Xiaohong Zhang, Junxiu Sheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBM4 regulates cellular senescence via miR1244/SERPINE1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-023-05563-z"}], "href": "https://doi.org/10.1038/s41419-023-05563-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36639375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36639375"}]}]}]}
Synonyms MIRN1244, HSA-MIR-1244, MIR1244, HSA-MIR-1244-1
NCBI Gene ID 100302285
API
Download Associations
Predicted Functions View MIR1244-1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1244-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1244-1's ARCHS4 Predicted Functions.

Functional Associations

MIR1244-1 has 553 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 17 datasets.

Click the + buttons to view associations for MIR1244-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1244-1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1244-1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing MIR1244-1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1244-1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with MIR1244-1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1244-1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1244-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1244-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1244-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1244-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR1244-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1244-1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1244-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of MIR1244-1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of MIR1244-1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with MIR1244-1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
WikiPathways Pathways 2014 pathways involving MIR1244-1 protein from the Wikipathways Pathways 2014 dataset.