{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn osteosarcoma, miR‑1245b‑5p plays a critical role as a target within a regulatory axis involving the long non‑coding RNA HCG11 and the plakophilin 2 (PKP2) gene. Upregulated HCG11 acts as a molecular “sponge” for miR‑1245b‑5p, reducing its availability and thereby relieving its suppression of PKP2. This results in increased PKP2 expression, which in turn promotes cell proliferation, migration, and invasion while inhibiting apoptosis. Such findings highlight that miR‑1245b‑5p functions as a tumor‑suppressive molecule in osteosarcoma, with its inhibition contributing to disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of breast cancer, miR‑1245b‑5p has been evaluated along with miR‑92a‑3p for its potential involvement in tumor development and metastasis, with a particular focus on its relationship with the transcription factor GATA3. This study suggests that miR‑1245b‑5p may offer diagnostic and therapeutic value, prompting further investigation into its role and the molecular pathways it regulates in breast cancer patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hao Yan, Yong Zhou, Zhujiang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA HCG11 enhances osteosarcoma phenotypes by sponging miR-1245b-5p that directly inhibits plakophilin 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2010367"}], "href": "https://doi.org/10.1080/21655979.2021.2010367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34949159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34949159"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mahtab Yadollahi Farsani, Zeinab Amini Farsani, Shohreh Teimuri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deregulation of miR-1245b-5p and miR-92a-3p and their potential target gene, GATA3, in epithelial-mesenchymal transition pathway in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Rep (Hoboken) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cnr2.1955"}], "href": "https://doi.org/10.1002/cnr2.1955"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38173189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38173189"}]}]}]}