{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‑1248 plays context‐dependent regulatory roles in both tissue regeneration and cancer. In diabetic settings, particularly in human adipose‐derived stem cells (hADSCs) from patients with diabetes mellitus, reduced expression of miR‑1248 disrupts stem cell activity, differentiation, and angiogenesis. This defect occurs via impaired suppression of CITED2, an inhibitor of HIF‑1α, ultimately disturbing the cascade of growth factors essential for cellular proliferation and effective wound healing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nConversely, in non‑small cell lung cancer (NSCLC), miR‑1248 exhibits tumor‑suppressive properties. Here, the circular RNA circEPSTI1 functions as a sponge for miR‑1248, lowering its effective levels. Upregulation of miR‑1248 in NSCLC cells reduces the expression of the oncogenic protein TRIM24, thereby restricting both cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cervical cancer, a similar regulatory mechanism is observed where the oncogenic circular RNA circ_0001589 sequesters miR‑1248. This sequestration prevents miR‑1248 from suppressing its direct target, HMGB1, leading to enhanced epithelial‑mesenchymal transition, increased cell migration and invasion, and reduced cisplatin sensitivity. Thus, restoration of miR‑1248 activity or targeting the miR‑1248/HMGB1 axis may offer new therapeutic avenues in cervical cancer management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shune Xiao, Dan Zhang, Zhiyuan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diabetes-induced glucolipotoxicity impairs wound healing ability of adipose-derived stem cells-through the miR-1248/CITED2/HIF-1α pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103053"}], "href": "https://doi.org/10.18632/aging.103053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32294623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32294623"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tian Yang, Meng Li, Hong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of circEPSTI1 represses the proliferation and invasion of non-small cell lung cancer by inhibiting TRIM24 via miR-1248 upregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.06.106"}], "href": "https://doi.org/10.1016/j.bbrc.2020.06.106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32828310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32828310"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Teng Ma, Jianxin Guo, Jian Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0001589/miR-1248/HMGB1 axis enhances EMT-mediated metastasis and cisplatin resistance in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.23605"}], "href": "https://doi.org/10.1002/mc.23605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37431919"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37431919"}]}]}]}