MIR1249 Gene

HGNC Family Non-coding RNAs
Name microRNA 1249
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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It directly targets the PB2 coding region in influenza A viruses, effectively suppressing viral replication of both H5N1 and H1N1 strains, which underscores its role in the host’s innate antiviral response. In a different biological context, miR‐1249‐5p has been shown to promote osteogenic differentiation of adipose‐derived stem cells, suggesting therapeutic potential in conditions such as osteoporosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn lung cancers and normal epithelial cells, regulatory networks involving miR‐1249‐3p have been elucidated through its interactions with specific circular RNAs and transcription factors. In lung adenocarcinoma, circ_0010235 acts as an oncogenic sponge for miR‐1249‐3p, leading to the upregulation of HOXA13 and enhancement of malignant behaviors including proliferation, migration, invasion, and EMT. A parallel mechanism is observed in non‐small cell lung cancer, where circ_0001715 sequesters miR‐1249‐3p to elevate FGF5 expression and promote tumor progression. Moreover, in normal epithelial cells, inhibition of miR‐1249‐3p results in increased HOXA13 and downstream β‐catenin expression, which suggests a role for miR‐1249 in modulating cell adhesion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoxiang Chen, Kaixuan Zeng, Mu Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P53-induced miR-1249 inhibits tumor growth, metastasis, and angiogenesis by targeting VEGFA and HMGA2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-1188-3"}], "href": "https://doi.org/10.1038/s41419-018-1188-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30755600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30755600"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hongchun Shu, Jia Hu, Huiqiu Deng "}, {"type": "b", "children": [{"type": "t", "text": "miR-1249-3p accelerates the malignancy phenotype of hepatocellular carcinoma by directly targeting HNRNPK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Genomic Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mgg3.867"}], "href": "https://doi.org/10.1002/mgg3.867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31429522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31429522"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wen Dang, Zhen Zhu "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1249 targets four-jointed box kinase 1 and reduces cell proliferation, migration and invasion of colon adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3183"}], "href": "https://doi.org/10.1002/jgm.3183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32159255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32159255"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Rong Wang, Ying-Ying Zhang, Jian-Sheng Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The highly pathogenic H5N1 influenza A virus down-regulated several cellular MicroRNAs which target viral genome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13219"}], "href": "https://doi.org/10.1111/jcmm.13219"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28609011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28609011"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiao-Mei Yang, Ya-Qi Song, Liang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1249-5p regulates the osteogenic differentiation of ADSCs by targeting PDX1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Surg Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13018-020-02147-x"}], "href": "https://doi.org/10.1186/s13018-020-02147-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33407691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33407691"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jiancheng Liu, Zejun Fu "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a Novel circ_0010235/miR-1249-3p/HOXA13 Axis in Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-021-10181-5"}], "href": "https://doi.org/10.1007/s10528-021-10181-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35076814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35076814"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Quanjin Zhang, Feng Ding, Congcong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0001715 Functions as a miR-1249-3p Sponge to Accelerate the Progression of Non-small Cell Lung Cancer via Upregulating the Level of FGF5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-023-10344-6"}], "href": "https://doi.org/10.1007/s10528-023-10344-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36808266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36808266"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Chiara Mazziotta, Maria Rosa Iaquinta, Maria Letizia Tramarin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa-microRNA-1249-3p/Homeobox A13 axis modulates the expression of β-catenin gene in human epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-49837-0"}], "href": "https://doi.org/10.1038/s41598-023-49837-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38129477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38129477"}]}]}]}
Synonyms MIRN1249, HSA-MIR-1249
NCBI Gene ID 100302149
API
Download Associations
Predicted Functions View MIR1249's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1249's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1249's ARCHS4 Predicted Functions.

Functional Associations

MIR1249 has 365 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR1249 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1249 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1249 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1249 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1249 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1249 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1249 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing MIR1249 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1249 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1249 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1249 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1249 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.