{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn epithelial ovarian cancer, miR-1251-5p functions as an oncogenic microRNA by promoting cell proliferation and cell cycle progression. Its upregulation in ovarian cancer tissues and cell lines is associated with enhanced tumor growth and advanced disease stages. Mechanistically, miR-1251-5p targets and downregulates TBCC, a tubulin-binding cofactor that normally inhibits cell cycle progression and autophagy by modulating key proteins such as CDK4, LC3BII, α/β-tubulin, and p62. By suppressing TBCC, miR-1251-5p indirectly disrupts the regulation of these molecules, facilitating tumor progression and autophagy, particularly under nutrient-deprived conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Furthermore, the reversal of TBCC’s suppressive effects upon the restoration of miR-1251-5p levels in TBCC-overexpressing cells, along with the observation of increased Ki67 and LC3B expression in xenograft tumors, underlines the critical role of the miR-1251-5p/TBCC/α/β-tubulin axis in ovarian cancer progression. This regulatory pathway represents a promising therapeutic target for improving the management of ovarian cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yang Shao, Xiaomin Liu, Jiao Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1251-5p Promotes Carcinogenesis and Autophagy via Targeting the Tumor Suppressor TBCC in Ovarian Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymthe.2019.06.005"}], "href": "https://doi.org/10.1016/j.ymthe.2019.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31278033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31278033"}]}]}]}