{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn non‐small cell lung cancer, dysregulation of competing endogenous RNAs has revealed a crucial role for miR‑1252. In this context, circABCB10 acts as an oncogenic sponge that sequesters miR‑1252, thereby reducing its availability to target the transcription factor FOXR2. Elevated levels of circABCB10 lead to reduced miR‑1252–mediated FOXR2 suppression, promoting cell proliferation and migration as well as tumor growth in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In lung adenocarcinoma, a similar ceRNA network has been identified where the long noncoding RNA LINC00520 is upregulated and inversely correlated with miR‑1252‑5p. LINC00520 competitively binds miR‑1252‑5p, thereby lowering its effective concentration and consequently de‐repressing its target, FOXR2. This molecular interplay contributes to enhanced cellular proliferation, migration, and invasion, highlighting the tumor‐suppressive potential of miR‑1252‑5p when not inhibited by its ceRNA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "In pancreatic cancer, miR‑1252‑5p is significantly downregulated, and its reduced expression is associated with adverse clinical outcomes. Functional studies demonstrate that miR‑1252‑5p directly targets the 3′‑untranslated region of NEDD9, thereby inhibiting the SRC/STAT3 signaling cascade involved in the proliferation, migration, invasion, and epithelial–mesenchymal transition of pancreatic cancer cells. Moreover, miR‑1252‑5p is subject to negative regulation by the transcription factor Myb, underlining its role as a tumor suppressor and its potential as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xufeng Tian, Lin Zhang, Yan Jiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircABCB10 promotes nonsmall cell lung cancer cell proliferation and migration by regulating the miR-1252/FOXR2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27657"}], "href": "https://doi.org/10.1002/jcb.27657"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30417418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30417418"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xinyue Chen, Huimin Chen, Miaowen Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00520 accelerates lung adenocarcinoma progression via miR-1252-5p/FOXR2 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-020-00478-9"}], "href": "https://doi.org/10.1007/s13577-020-00478-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33464477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33464477"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuzheng Xue, Tielong Wu, Yingyue Sheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1252-5p, regulated by Myb, inhibits invasion and epithelial-mesenchymal transition of pancreatic cancer cells by targeting NEDD9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203344"}], "href": "https://doi.org/10.18632/aging.203344"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34314382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34314382"}]}]}]}