MIR1253 Gene

HGNC Family Non-coding RNAs
Name microRNA 1253
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nExtensive research across multiple cancer types has revealed that miR‑1253 primarily functions as a tumor suppressor. In pancreatic ductal adenocarcinoma, for example, the upregulated circular RNA circ_0030235 was shown to exert its oncogenic effects partly by sponging miR‑1253, thereby diminishing its regulatory influence on downstream targets. Similarly, in non‑small‑cell lung carcinoma, miR‑1253 is found significantly down‑regulated, and its restoration suppresses cell proliferation, migration, and invasion through the direct targeting of the WNT5A (long) isoform. In medulloblastoma, epigenetic silencing via hypermethylation reduces miR‑1253 expression, facilitating tumor cell proliferation by failing to repress oncogenic targets such as CDK6 and CD276."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn additional tumor contexts, similar tumor‑suppressive roles for miR‑1253 have been described. In osteosarcoma, the circular RNA circNASP sequesters miR‑1253, which normally targets FOXF1; this sequestration leads to enhanced cell proliferation and invasion. In prostate and colon cancers, miR‑1253 downregulation correlates with advanced disease and poor prognosis, acting through the regulation of EZH2 expression to impair oncogenic processes. Although its role in osteosarcoma is not yet fully defined, these findings collectively indicate that the attenuation of miR‑1253 activity by mechanisms such as ceRNA sponging or epigenetic silencing can facilitate tumor progression. Its emerging involvement—even in studies addressing chemoresistance in non‑small‑cell lung cancer—positions miR‑1253 as a promising prognostic biomarker and potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meiyue Liu, Yue Zhang, Jie Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1253 suppresses cell proliferation and invasion of non-small-cell lung carcinoma by targeting WNT5A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-017-0218-x"}], "href": "https://doi.org/10.1038/s41419-017-0218-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29415994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29415994"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yi Xu, Yue Yao, Ping Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated circular RNA circ_0030235 predicts unfavorable prognosis in pancreatic ductal adenocarcinoma and facilitates cell progression by sponging miR-1253 and miR-1294."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.12.088"}], "href": "https://doi.org/10.1016/j.bbrc.2018.12.088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30591218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30591218"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ranjana K Kanchan, Naveenkumar Perumal, Pranita Atri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Pathol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bpa.12829"}], "href": "https://doi.org/10.1111/bpa.12829"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32145124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32145124"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lipeng Huang, Mangmang Chen, Jun Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circNASP modulates the malignant behaviors in osteosarcoma via miR-1253/FOXF1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.04.131"}], "href": "https://doi.org/10.1016/j.bbrc.2018.04.131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29678578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29678578"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yanbo Chen, Meng Gu, Chong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA FOXC2-AS1 facilitates the proliferation and progression of prostate cancer via targeting miR-1253/EZH2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.10.085"}], "href": "https://doi.org/10.1016/j.gene.2018.10.085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30389560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30389560"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Daye Yang, Dewei Zhang "}, {"type": "b", "children": [{"type": "t", "text": "miR-1253, a novel tumor suppressor gene in colon cancer, is associated with poor patients prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10238-021-00706-y"}], "href": "https://doi.org/10.1007/s10238-021-00706-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33837882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33837882"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jianwen Mo, Tiansheng Zheng, Li Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1253 Suppresses Cell Proliferation Migration and Invasion of Osteosarcoma by Targeting MMP9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033821995278"}], "href": "https://doi.org/10.1177/1533033821995278"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34036868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34036868"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hua He, Tian Li "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0000190 Promotes NSCLC Cell Resistance to Cisplatin via the Modulation of the miR-1253/IL-6 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anal Cell Pathol (Amst) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2024/6647810"}], "href": "https://doi.org/10.1155/2024/6647810"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38440120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38440120"}]}]}]}
Synonyms HSA-MIR-1253, MIRN1253
NCBI Gene ID 100302208
API
Download Associations
Predicted Functions View MIR1253's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1253's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1253's ARCHS4 Predicted Functions.

Functional Associations

MIR1253 has 594 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR1253 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1253 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1253 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1253 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1253 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1253 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1253 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR1253 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1253 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1253 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1253 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1253 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.