{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn recent work on exosomal microRNAs in breast cancer, miR‑1255a was identified as one of the key microRNAs expressed in both exosomes and original cell samples. Functional analyses revealed that miR‑1255a modulates the TGF‑β signaling pathway via regulation of SMAD4, suggesting that it plays an important role in controlling cellular processes related to tumor progression and cell cycle regulation. Its expression was found to correlate with poor overall survival, indicating that miR‑1255a could serve both as a prognostic biomarker and as a potential therapeutic target in breast cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ying Xin, Xueqiang Wang, Kexin Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of exosomal miR-455-5p and miR-1255a as therapeutic targets for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20190303"}], "href": "https://doi.org/10.1042/BSR20190303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31763681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31763681"}]}]}]}