{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have implicated the MIR1255 gene family in cancer biology. In an analysis of exosomal microRNAs from breast cancer cells, a related member—miR‐1255a—was found to regulate SMAD4, thereby modulating the TGF‑β signaling pathway. Its consistent expression in both exosomal and cellular samples was associated with poor overall survival, suggesting a role in promoting oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, investigation of prostate cancer revealed that miR‑1255b‑5p, derived from MIR1255B1, is significantly upregulated in patient blood compared with benign cases. Elevated levels of miR‑1255b‑5p reliably distinguished malignant cases—and particularly aggressive disease—from indolent forms. Functional studies demonstrated that downregulation of miR‑1255b‑5p suppressed the proliferative, invasive, and migratory capacities of prostate cancer cells, an effect that was reversed by inhibition of EPB41L1. These findings support the potential utility of MIR1255B1 as both a noninvasive diagnostic biomarker and a therapeutic target in prostate cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ying Xin, Xueqiang Wang, Kexin Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of exosomal miR-455-5p and miR-1255a as therapeutic targets for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20190303"}], "href": "https://doi.org/10.1042/BSR20190303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31763681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31763681"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuling Zhao, Xiaochun Tang, Yifan Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnostic significance of microRNA-1255b-5p in prostate cancer patients and its effect on cancer cell function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2009413"}], "href": "https://doi.org/10.1080/21655979.2021.2009413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34895055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34895055"}]}]}]}