{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence underscores a crucial tumor‐suppressive role for miR‑1256 in gastrointestinal malignancies. In colorectal cancer, miR‑1256 has been investigated as a promising biomarker for patient prognosis, with its altered levels correlating with disease outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, in gastric cancer tissues, dysregulated expression of circular RNAs has been found to inversely correlate with miR‑1256 levels, suggesting that when certain circRNAs (such as circ‑DCAF6) are upregulated, they act as sponges that sequester miR‑1256, thereby diminishing its tumor‐suppressive activity and promoting oncogenic features including enhanced proliferation, invasion, and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, another study in gastric cancer demonstrated that circ‑HECTD1 exerts tumor‐promoting effects by directly targeting and inhibiting miR‑1256; this inhibition leads to increased expression of USP5 and subsequent activation of proliferative and survival pathways through β‑catenin and c‑Myc signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " These results reinforce the concept that miR‑1256 normally functions to constrain oncogenic signaling.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, genetic studies in pancreatic ductal adenocarcinoma have identified a risk allele within a long noncoding RNA (lnc‑SMC2‑1) that is predicted to disrupt its binding with miR‑1256. This perturbation potentially impairs the regulation of key cell cycle genes, such as CDKN2B, thereby influencing tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Together, these findings highlight that miR‑1256 plays an important role in modulating cell cycle regulators and oncogenic signaling pathways through its interactions with noncoding RNAs, setting a foundation for its application as both a prognostic biomarker and a potential therapeutic target in gastrointestinal cancers.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Z-Y Liu, L Yang, H-Y Chang "}, {"type": "b", "children": [{"type": "t", "text": "Clinicopathologic and prognostic relevance of miR-1256 in colorectal cancer: a preliminary clinical study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201811_16391"}], "href": "https://doi.org/10.26355/eurrev_201811_16391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30536313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30536313"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ligang Wu, Deshui Liu, Yu Yang "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced expression of circular RNA circ-DCAF6 predicts adverse prognosis and promotes cell progression via sponging miR-1231 and miR-1256 in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Pathol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexmp.2019.104273"}], "href": "https://doi.org/10.1016/j.yexmp.2019.104273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31226266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31226266"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Juan Cai, Zhiqiang Chen, Jinguo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circHECTD1 facilitates glutaminolysis to promote gastric cancer progression by targeting miR-1256 and activating β-catenin/c-Myc signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1814-8"}], "href": "https://doi.org/10.1038/s41419-019-1814-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31371702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31371702"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chiara Corradi, Manuel Gentiluomo, László Gajdán, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.33475"}], "href": "https://doi.org/10.1002/ijc.33475"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33534179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33534179"}]}]}]}