{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have implicated miR‐1260A as a critical regulator whose dysregulation is associated with diverse pathological conditions. In particular, profiling of circulating microRNAs in influenza patients revealed that miR‐1260 (likely corresponding to miR‐1260A) is among a panel of highly dysregulated miRNAs in whole blood and infected cells, suggesting that it may play a role in modulating host responses during viral infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the oncology arena, aberrant expression of miR‐1260A is emerging as a potential biomarker in several cancers. In prostate cancer, for example, miR‐1260 (assumed here to represent miR‐1260A) is significantly overexpressed compared to controls, with bioinformatic analyses linking this miRNA to pathways implicated in cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In breast cancer, plasma levels of miR‐1260A have been reported to be significantly up‐regulated, and pathway analyses suggest its involvement in critical signaling networks such as the Hippo and TGF‑β cascades."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Conversely, in epithelial ovarian cancer, exosomal miR‐1260A levels are markedly decreased, highlighting its potential utility as a diagnostic and prognostic biomarker for this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdding further complexity, recent evidence indicates that miR‐1260A’s sequence is embedded within certain tRNA‐derived fragments (tRFs), suggesting that it may function dually as a canonical miRNA and as part of a tRF‐miRNA system. This dual identity might influence gene regulatory networks in cancer and contribute to its utility as a circulating biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Collectively, these findings position miR‐1260A as both a functional regulator and a promising biomarker across different disease contexts, warranting further mechanistic exploration and validation in clinical settings.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Paul A Tambyah, Sugunavathi Sepramaniam, Jaminah Mohamed Ali, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Plasma exosomal "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "miR-1260a, miR-7977"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "miR-192-5p"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " as diagnostic biomarkers in epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Future Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/fon-2022-0321"}], "href": "https://doi.org/10.2217/fon-2022-0321"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35893704"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35893704"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shaharbhanu A Hussain, Kunhi Valappil Deepak, Dechamma Pandyanda Nanjappa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparative expression analysis of tRF-3001a and tRF-1003 with corresponding miRNAs (miR-1260a and miR-4521) and their network analysis with breast cancer biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-021-06732-z"}], "href": "https://doi.org/10.1007/s11033-021-06732-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34661810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34661810"}]}]}]}