MIR1260B Gene

HGNC Family Non-coding RNAs
Name microRNA 1260b
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‑1260b is emerging as an important oncomiR whose aberrant upregulation is observed in several malignancies. For instance, elevated miR‑1260b levels in colorectal cancer correlate with lymph node metastasis and venous invasion, indicating a poorer prognosis, while in hepatocellular carcinoma, its dysregulation is implicated in enhanced cell migration and invasion. In non‑small cell lung cancer (NSCLC) and breast cancer, high miR‑1260b expression is associated with aggressive tumor characteristics such as increased tumor size, advanced stage, and reduced overall survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic investigations reveal that miR‑1260b exerts its oncogenic functions through diverse regulatory pathways. In lung adenocarcinoma, exosomal miR‑1260b promotes cell invasion partly by inhibiting secreted antagonists such as sFRP1 and Smad4, while in NSCLC it enhances cell proliferation and tumor growth by directly targeting SOCS6, thereby activating KIT signaling under the regulation of transcription factor YY1. Under hypoxic conditions in vascular smooth muscle cells, miR‑1260b is robustly induced and directly targets growth differentiation factor 11 (GDF11), leading to attenuation of TGF‑β/Smad‑dependent signaling and increased cellular proliferation. Moreover, in nucleus pulposus cells, miR‑1260b targets TCF7L2 and mitigates lipopolysaccharide‑induced degenerative changes, and in hepatocellular carcinoma its modulation of RGS22 contributes to cell migration and invasion. Additional studies in NSCLC have identified that exosomal miR‑1260b targets HIPK2 in endothelial cells, promoting angiogenesis, enhancing cellular mobility, and contributing to drug resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings establish miR‑1260b as a multifunctional regulator of tumorigenesis and cellular homeostasis. By modulating key signaling pathways and targeting multiple tumor suppressor genes, miR‑1260b not only drives processes such as cell proliferation, invasion, and angiogenesis in cancer but also influences phenotypic alterations in non‑malignant cells under stress conditions. Its strong association with aggressive disease features and its presence in exosomes underscore its promise as both a prognostic biomarker and a potential therapeutic target across a spectrum of cancers and degenerative disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}, {"type": "fg_fs", "start_ref": "6", "end_ref": "9"}, {"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Deng-Rui Liu, Quan-Lin Guan, Ming-Tai Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1260b is a Potential Prognostic Biomarker in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/msm.898733"}], "href": "https://doi.org/10.12659/msm.898733"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27399918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27399918"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoying Li, Hongxia Song, Zhirong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1260b promotes cell migration and invasion of hepatocellular carcinoma by targeting the regulator of G-protein signaling 22."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biotechnol Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10529-017-2455-6"}], "href": "https://doi.org/10.1007/s10529-017-2455-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29038925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29038925"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yang Xia, Ke Wei, Feng-Ming Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1260b, mediated by YY1, activates KIT signaling by targeting SOCS6 to regulate cell proliferation and apoptosis in NSCLC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1390-y"}], "href": "https://doi.org/10.1038/s41419-019-1390-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30737371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30737371"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sunyoung Park, Jungho Kim, Yoonjung Cho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promotion of tumorigenesis by miR-1260b-targeting CASP8: Potential diagnostic and prognostic marker for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15345"}], "href": "https://doi.org/10.1111/cas.15345"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35325509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35325509"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhijian Huang, Shijian Zhen, Liangzi Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-1260b Promotes Breast Cancer Cell Migration and Invasion by Downregulating CCDC134."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Gene Ther (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1566523222666220901112314"}], "href": "https://doi.org/10.2174/1566523222666220901112314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36056852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36056852"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Minhyeong Seong, Hara Kang "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced miR-1260b regulates vascular smooth muscle cell proliferation by targeting GDF11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMB Rep (2020)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31818357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31818357"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yang Xia, Ke Wei, Liu-Qing Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosome-mediated transfer of miR-1260b promotes cell invasion through Wnt/β-catenin signaling pathway in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29578"}], "href": "https://doi.org/10.1002/jcp.29578"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32026462"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32026462"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dong Ha Kim, Hyojeong Park, Yun Jung Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04024-9"}], "href": "https://doi.org/10.1038/s41419-021-04024-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34321461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34321461"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Shijie Chen, Guixia Shi, Jin Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1260b protects against LPS-induced degenerative changes in nucleus pulposus cells through targeting TCF7L2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-021-00655-4"}], "href": "https://doi.org/10.1007/s13577-021-00655-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35165858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35165858"}]}]}]}
Synonyms MIR-1260B
NCBI Gene ID 100422991
API
Download Associations
Predicted Functions View MIR1260B's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1260B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1260B's ARCHS4 Predicted Functions.

Functional Associations

MIR1260B has 1,284 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR1260B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1260B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1260B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1260B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1260B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1260B gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1260B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1260B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR1260B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR1260B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR1260B gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1260B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1260B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1260B gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1260B gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.