{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn papillary thyroid carcinoma, miR‑1261 serves as a key tumor‐suppressive regulator by normally targeting and downregulating the expression of C8orf4. However, a highly expressed circular RNA (circZFR) acts as a competing endogenous RNA (ceRNA) that sponges miR‑1261, leading to upregulation of C8orf4. This derepression promotes increased proliferation, migration, and invasion of cancer cells, highlighting an oncogenic mechanism driven by the loss of miR‑1261 activity through circRNA sequestration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn glioma, a similar regulatory interplay has been observed where miR‑1261 directly binds to and inhibits the expression of circ‑PTPRZ1. This interaction results in the suppression of PAK1 phosphorylation, thereby reducing glioma cell proliferation and invasion while promoting apoptosis. By modulating the circ‑PTPRZ1/PAK1 axis, miR‑1261 functions as an important negative regulator of oncogenic signaling in glioma cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn liver cancer, miR‑1261 is also central to controlling tumor progression. Here, the long non‑coding RNA BCAR4 directly binds to miR‑1261, leading to its downregulation. As a result, the suppression of ANAPC11 by miR‑1261 is relieved, thereby increasing ANAPC11 expression and promoting liver cancer cell proliferation, migration, and invasion. This axis underlines how the inhibition of miR‑1261 by oncogenic non‑coding RNAs contributes to hepatic tumor development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hong Wei, Lin Pan, Deyou Tao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.05.174"}], "href": "https://doi.org/10.1016/j.bbrc.2018.05.174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29842886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29842886"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Feng Zhang, Shu-Rong Mai, Fei-Peng Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1261/circ-PTPRZ1/PAK1 pathway regulates glioma cell growth and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-019-00271-3"}], "href": "https://doi.org/10.1007/s13577-019-00271-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31364003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31364003"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yu Zhang, Hongyan Zhou "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA BCAR4 promotes liver cancer progression by upregulating ANAPC11 expression through sponging miR‑1261."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2020.4586"}], "href": "https://doi.org/10.3892/ijmm.2020.4586"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32319544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32319544"}]}]}]}