{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐1262 has emerged as a key regulatory molecule in several disease contexts. In lung cancer, a variant in the miR‐1262 enhancer (rs12740674) was found to reduce miR‐1262 expression via chromosomal looping, with consequent promotion of tumor cell proliferation likely through modulation of downstream targets such as ULK1 and RAB3D."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast cancer, miR‐1262 acts as a tumor suppressor by negatively regulating LRP8, thereby impairing cell proliferation, clonogenicity, invasion, and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nAdditionally, differential expression of miR‐1262 has been implicated in neurological and cardiovascular disorders. In treatment‐resistant schizophrenia, altered miR‐1262 levels in peripheral blood mononuclear cells highlight its potential role in the pathogenesis of the disorder and its value as an early diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In the context of sepsis, exosomal hsa‐miR‐1262 from patient serum was shown to target SLC2A1 in myocardial cells; this interaction leads to impaired glycolysis and increased cell apoptosis, thereby contributing to septic myocardial injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n \nIn colon cancer, miR‐1262 is downregulated and functions as an antitumor miRNA. Its overexpression directly inhibits fibroblast growth factor receptor 1 (FGFR1), reducing malignant behaviors such as proliferation, invasion, and migration. Moreover, the transcriptional regulation of miR‐1262 by NF‐κB further integrates it into a regulatory axis that modulates colon carcinogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kaipeng Xie, Mengxi Chen, Meng Zhu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Exosomes derived from the blood of patients with sepsis regulate apoptosis and aerobic glycolysis in human myocardial cells via the hsa‑miR‑1262/SLC2A1 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2022.12635"}], "href": "https://doi.org/10.3892/mmr.2022.12635"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35137927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35137927"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Weilin Zhang, Zhongcheng Huang, Zhigang Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-κB downstream miR-1262 disturbs colon cancer cell malignant behaviors by targeting FGFR1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3724/abbs.2023235"}], "href": "https://doi.org/10.3724/abbs.2023235"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37867436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37867436"}]}]}]}