{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐1263 has emerged as an important regulator in the differentiation of human embryonic stem cells. Overexpression studies indicate that miR‐1263 can accelerate and enhance endoderm differentiation by destabilizing pluripotency. One key mechanism for this effect involves the targeting and subsequent downregulation of KLF4—a transcription factor that normally sustains the pluripotent state. The downregulation of KLF4 by miR‐1263 leads to a shift in cell fate decisions, promoting the specification of endoderm lineages."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of infectious diseases, altered levels of circulating miR‐1263 have been observed during dengue virus infection. Studies comparing dengue‐infected pediatric patients to those with other acute febrile illnesses found that miR‐1263 levels were significantly reduced during both the febrile and convalescent phases of infection. Although these alterations do not distinguish between different severities of dengue, they support a potential role for miR‐1263 as an early and late biomarker of dengue virus infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, miR‐1263 contained within extracellular vesicles has been implicated in intercellular communication within the liver tumor microenvironment. Specifically, miR‐1263 transferred from hepatic stellate cells to liver cancer cells has been shown to modulate tumor cell behavior by reducing migration and invasion. This microRNA also influences the expression of factors involved in extracellular matrix remodeling and angiogenesis, ultimately affecting multicellular spheroid growth. These findings highlight a novel role for EV‐mediated miR‐1263 signaling in modulating the behavior of liver cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Daichi Ishikawa, Ulf Diekmann, Jan Fiedler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNome Profiling of Purified Endoderm and Mesoderm Differentiated from hESCs Reveals Functions of miR-483-3p and miR-1263 for Cell-Fate Decisions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Reports (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stemcr.2017.10.011"}], "href": "https://doi.org/10.1016/j.stemcr.2017.10.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29141233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29141233"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Methee Sriprapun, Jittraporn Rattanamahaphoom, Pimolpachr Sriburin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression of circulating hsa-miR-126-3p in dengue-infected Thai pediatric patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathog Glob Health (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/20477724.2022.2088465"}], "href": "https://doi.org/10.1080/20477724.2022.2088465"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35708203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35708203"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anuradha Moirangthem, Piyush Gondaliya, Irene K Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular vesicle‑mediated miR‑126‑3p transfer contributes to inter‑cellular communication in the liver tumor microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2023.5479"}], "href": "https://doi.org/10.3892/ijo.2023.5479"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36660950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36660950"}]}]}]}