{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‐1264 has emerged as a pivotal regulatory molecule in the vascular system, influencing endothelial cell behavior and smooth muscle cell function. In one study investigating atherosclerotic plaque destabilization, endothelial cells treated with serum exosomes from patients with unstable carotid plaques exhibited downregulation of miR‐1264 in the presence of a circRNA (circRNA1006896), which in turn was linked to increased DNMT1 expression and consequent STAT3 phosphorylation. This cascade likely contributes to enhanced endothelial proliferation and migration, events that can promote plaque vulnerability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn vascular smooth muscle cells, decreased levels of miR‐1264 were similarly implicated in dysregulated gene expression. Here, pro‐inflammatory stimuli such as TNF‐α and IGF‐1 reduced miR‐1264 expression, thereby alleviating its repression of DNMT1. The resultant DNMT1 upregulation induced hypermethylation of the SOCS3 promoter, suppressing SOCS3 expression and potentially promoting neointimal hyperplasia—a key process in restenosis following vascular injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in vascular pathology, miR‐1264 is also involved in the modulation of oncogenic processes. In colorectal cancer, for instance, the long noncoding RNA SOCS2‐AS1 acts by restraining miR‐1264, which leads to increased expression of the tumor‐suppressor gene SOCS2. This SOCS2‐AS1/miR‐1264/SOCS2 axis is associated with reduced cellular proliferation, migration, and invasion, thereby curtailing tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in gastric cancer, a circular RNA designated circ1322 functions as a sponge for miR‐1264. By sequestering miR‐1264, circ1322 alleviates the microRNA’s inhibitory effect on its target gene QKI—thereby modulating hedgehog pathway activity and influencing cellular proliferation and metastasis. This ceRNA network underscores the potential of miR‐1264 as a therapeutic target in gastric malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chandra S Boosani, Kajari Dhar, Devendra K Agrawal "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of hsa-miR-1264 contributes to DNMT1-mediated silencing of SOCS3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-015-3882-x"}], "href": "https://doi.org/10.1007/s11033-015-3882-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26047583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26047583"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan Wen, Yao Chun, Zhong Qing Lian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circRNA‑0006896‑miR1264‑DNMT1 axis plays an important role in carotid plaque destabilization by regulating the behavior of endothelial cells in atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.11950"}], "href": "https://doi.org/10.3892/mmr.2021.11950"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33649864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33649864"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhihai Zheng, Xiaoxiao Li, Heyi You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103276"}], "href": "https://doi.org/10.18632/aging.103276"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32437330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32437330"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wenyi Wu, Yiqi Cai, Jinji Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA Circ_0001322 inhibits gastric cancer progression by modulating the miR-1264/QKI axis and suppressing the Hedgehog pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14715/cmb/2024.70.5.27"}], "href": "https://doi.org/10.14715/cmb/2024.70.5.27"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38814217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38814217"}]}]}]}