MIR1265 Gene

HGNC Family Non-coding RNAs
Name microRNA 1265
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn a study investigating the molecular drivers of bladder cancer metastasis, circular RNAs such as circPICALM were found to modulate aggressive tumor behavior. Although this work (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "did not directly assess MIR1265 function, it alludes to the broader regulatory network involving microRNAs that may influence metastatic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, research in gastric cancer precisely delineated the role of MIR1265 as a tumor suppressor. This study (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "demonstrated that reduced expression of MIR1265 is associated with increased tumor size, whereas its overexpression suppressed cellular proliferation and autophagy and promoted apoptosis. Mechanistically, MIR1265 directly targets calcium binding protein 39 (CAB39), an upstream regulator of the AMPK-mTOR signaling pathway, thereby inhibiting oncogenic autophagy. Modulation of CAB39 levels or interference with autophagic processes reversed the effects of MIR1265 alteration, underscoring its potential as a therapeutic target in gastric cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTogether, these findings suggest that while the involvement of MIR1265 in bladder cancer metastasis remains to be fully elucidated within the context of complex circular RNA networks, its clearly defined tumor‐suppressive function in gastric cancer—marked by inhibition of proliferation and autophagy through targeting of the AMPK-mTOR pathway—highlights its therapeutic promise across distinct oncologic settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dong Yan, Wei Dong, Qingqing He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circPICALM sponges miR-1265 to inhibit bladder cancer metastasis and influence FAK phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2019.08.074"}], "href": "https://doi.org/10.1016/j.ebiom.2019.08.074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31648990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31648990"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhipeng Xu, Zheng Li, Weizhi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2019.02.026"}], "href": "https://doi.org/10.1016/j.canlet.2019.02.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30779944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30779944"}]}]}]}
Synonyms MIRN1265, HSA-MIR-1265
NCBI Gene ID 100302116
API
Download Associations
Predicted Functions View MIR1265's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1265's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1265's ARCHS4 Predicted Functions.

Functional Associations

MIR1265 has 238 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR1265 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1265 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1265 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1265 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1265 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1265 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1265 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1265 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1265 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1265 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1265 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1265 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.