MIR1266 Gene

HGNC Family Non-coding RNAs
Name microRNA 1266
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-1266 plays a multifaceted role in tumor biology, acting as a tumor suppressor in several contexts. In gastric cancer, downregulation of miR-1266 leads to an increase in hTERT expression, which in turn promotes tumor growth and invasion, whereas restoration of miR-1266 suppresses hTERT levels and inhibits tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colorectal cancer, investigations have shown that miR-1266 dampens malignant behavior by targeting genes involved in epithelial–mesenchymal transition; one study demonstrated that decreased miR-1266-3p expression is associated with increased P4HA3 levels, leading to enhanced proliferation, metastasis, and EMT."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in prostate cancer, miR-1266 can suppress tumor growth by binding the 3′ UTR of the anti‐apoptotic gene BCL2 to induce apoptosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and in papillary thyroid carcinoma, modulation of miR-1266 impacts metastatic potential and cell proliferation, suggesting its therapeutic relevance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, miR-1266 appears to exert oncogenic effects in other cancer types. In cervical cancer, miR-1266 is upregulated, with elevated serum levels correlating with increased cell viability, proliferation, migration, invasion, and ultimately poorer overall survival, a function mediated by its targeting of the tumor suppressor DAB2IP."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Additionally, in estrogen receptor–positive breast cancer, high levels of miR-1266 are significantly associated with a higher risk of recurrence and metastasis, and may influence tamoxifen response through effects on the HOXB13:IL17BR axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings underscore the context-dependent functions of miR-1266 in cancer. While in certain settings—such as gastric, colorectal, prostate, and papillary thyroid carcinomas—miR-1266 acts as a tumor suppressor via inhibition of oncogenic pathways, in others, notably cervical and ER-positive breast cancers, its upregulation contributes to tumor progression and chemoresistance. These diverse roles highlight miR-1266 as both a promising biomarker for disease prognosis and a potential therapeutic target, warranting further investigation into its molecular mechanisms across different tumor types.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "L Chen, M-H Lü, D Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2013.553"}], "href": "https://doi.org/10.1038/cddis.2013.553"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24481448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24481448"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "X-P Shen, X Ling, H Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low expression of microRNA-1266 promotes colorectal cancer progression via targeting FTO."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201812_16516"}], "href": "https://doi.org/10.26355/eurrev_201812_16516"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30556861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30556861"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hailang Zhou, Shu Huang, Changjiang Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1266-3p Suppresses Epithelial-Mesenchymal Transition in Colon Cancer by Targeting P4HA3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anal Cell Pathol (Amst) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/1542117"}], "href": "https://doi.org/10.1155/2022/1542117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35433237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35433237"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shiva Ostadrahimi, Manuchehr Abedi Valugerdi, Moustapha Hassan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1266-5p and miR-185-5p Promote Cell Apoptosis in Human Prostate Cancer Cell Lines"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.22034/APJCP.2018.19.8.2305"}], "href": "https://doi.org/10.22034/APJCP.2018.19.8.2305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30141307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30141307"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Y-T Fu, H-B Zheng, D-Q Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1266 suppresses papillary thyroid carcinoma cell metastasis and growth via targeting FGFR2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201806_15166"}], "href": "https://doi.org/10.26355/eurrev_201806_15166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29917195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29917195"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jinming Wang, Yuehua Liu, Xiaofang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1266 promotes cell proliferation, migration and invasion in cervical cancer by targeting DAB2IP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Basis Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2018.09.028"}], "href": "https://doi.org/10.1016/j.bbadis.2018.09.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30261286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30261286"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Elif Demirdogen Sevinc, Unal Egeli, Gulsah Cecener, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of miR-1266 with recurrence/metastasis potential in estrogen receptor positive breast cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2015.16.1.291"}], "href": "https://doi.org/10.7314/apjcp.2015.16.1.291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25640367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25640367"}]}]}]}
Synonyms MIRN1266, MIR-1266, HSA-MIR-1266
NCBI Gene ID 100302202
API
Download Associations
Predicted Functions View MIR1266's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1266's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1266's ARCHS4 Predicted Functions.

Functional Associations

MIR1266 has 239 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR1266 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1266 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1266 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1266 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1266 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1266 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1266 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1266 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR1266 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1266 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1266 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1266 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1266 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.