{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma associated with high aflatoxin B1 exposure, a polymorphism in the precursor miR‐1268a (rs28599926) has been identified as a significant risk and prognostic factor. Carriers of the T allele exhibit a markedly increased risk of HCC, which is accompanied by larger tumor size, higher portal vein involvement, dedifferentiation, and elevated levels of aflatoxin B1 adducts. This variant is also linked to an increased frequency of TP53 mutations and appears to modulate the expression of ADAMTS4 mRNA, suggesting that miR‐1268a plays an important role in tumor aggressiveness and patient outcome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of heart failure, miR‐1268a is up‐regulated in myocardial AC16 cells treated with Angiotensin II, and it contributes to the pathological process by targeting CD36. The elevated levels of miR‐1268a mediate a decrease in fatty acid uptake, ATP production, and an increase in oxidative stress and HF markers (BNP and ST2), underscoring its role in metabolic regulation under stress conditions. Conversely, inhibition of miR‐1268a mitigates these deleterious effects, indicating that miR‐1268a is a critical regulator of cardiomyocyte function during heart failure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xi-Dai Long, Xiao-Ying Huang, Jin-Guang Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in the precursor microRNAs and aflatoxin B1-related hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22350"}], "href": "https://doi.org/10.1002/mc.22350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26152337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26152337"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gang Xu, Yi Xu, Ying Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1268a Regulates Fatty Acid Metabolism by Targeting CD36 in Angiotensin II-induced Heart Failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Biophys (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12013-024-01268-y"}], "href": "https://doi.org/10.1007/s12013-024-01268-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38619643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38619643"}]}]}]}