{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn atherosclerosis, angiogenesis plays a critical role in plaque instability, and emerging studies have identified noncoding RNA networks as pivotal regulators of this process. One investigation uncovered that silencing the circular RNA circSCRG1 leads to an up‐regulation of miR‑1268b, which in turn increases the expression of nuclear receptor NR4A1 and promotes ox‑LDL–induced angiogenesis. Conversely, treatment with a combination of tetramethylpyrazine and paeoniflorin (TMP‑PF) enhances circSCRG1 expression, enabling miR‑1268b to mediate suppression of NR4A1 and thereby inhibit angiogenic responses. This evidence positions miR‑1268b as a key mediator in the circSCRG1/miR‑1268b/NR4A1 axis, making it a promising target for strategies aimed at stabilizing atherosclerotic plaques."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn a seemingly distinct field, research on the DIRAS2 gene has revealed its high expression in crucial brain regions such as the hippocampus and cerebral cortex, with fluctuations during development that are consistent with the pathomechanisms of attention‑deficit/hyperactivity disorder (ADHD). Although miR‑1268b was not directly examined in this context, these findings underscore the broader importance of RNA‐mediated regulation in neurodevelopment and suggest that noncoding RNAs may serve as integral modulators in diverse biological processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nSupporting the concept of complex gene regulatory networks, another study demonstrated that downregulation of Diras2 in murine hippocampal cells significantly altered the expression of over 1,600 genes involved in neurodevelopment. The extensive impact on gene networks further emphasizes the critical role of finely tuned regulatory systems—including those governed by noncoding RNAs like miR‑1268b—in maintaining cellular function and in the etiology of multifactorial diseases"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rong Yuan, Qiqi Xin, Xiaochang Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a Novel Angiogenesis Signalling circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the Regulatory Effects of TMP-PF In Vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Molecules (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/molecules28031271"}], "href": "https://doi.org/10.3390/molecules28031271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36770940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36770940"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lena Grünewald, Nils Becker, Annika Camphausen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the ADHD candidate gene Diras2 in the brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neural Transm (Vienna) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00702-018-1867-3"}], "href": "https://doi.org/10.1007/s00702-018-1867-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29488099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29488099"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lena Grünewald, Andreas G Chiocchetti, Heike Weber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of the ADHD Candidate Gene "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Diras2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in Murine Hippocampal Primary Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Atten Disord (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1087054718822129"}], "href": "https://doi.org/10.1177/1087054718822129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30623719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30623719"}]}]}]}