{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma associated with hepatitis B virus infection, miR-1269b is reported to be up-regulated in both tumor tissues and cell lines. Although the precise regulatory pathways by which HBV influences miR-1269b expression remain to be fully elucidated, its enhanced levels in HCC suggest an oncogenic role that may contribute to the occurrence and progression of the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In contrast, studies in gastric cancer reveal that miR-1269b is expressed at lower levels in tumor tissues and cell lines. Functional experiments demonstrated that restoring miR-1269b expression can suppress malignancy by inhibiting cell proliferation, migration, and invasion, effects mediated through direct targeting of METTL3. This indicates that, in the context of gastric cancer, miR-1269b appears to act as a tumor suppressor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Additionally, investigations into genetic predisposition have explored a single-nucleotide polymorphism in miR-1269b (G>C), examining its association with the risk of developing oral premalignant lesions, oral squamous cell carcinoma, and pharyngeal squamous cell carcinoma. These findings suggest that variations within the miR-1269b gene may influence susceptibility to these head and neck cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiao-Xiao Kong, Yan-Ru Lv, Li-Ping Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HBx-induced MiR-1269b in NF-κB dependent manner upregulates cell division cycle 40 homolog (CDC40) to promote proliferation and migration in hepatoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-016-0949-y"}], "href": "https://doi.org/10.1186/s12967-016-0949-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27349221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27349221"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jian Kang, Xu Huang, Weiguo Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1269b inhibits gastric cancer development through regulating methyltransferase-like 3 (METTL3)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1909951"}], "href": "https://doi.org/10.1080/21655979.2021.1909951"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33818282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33818282"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hung-Chih Chen, Yu-Kai Tseng, Chao-Chuan Chi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants in microRNA-146a (C>G) and microRNA-1269b (G>C) are associated with the decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Oral Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.archoralbio.2016.08.010"}], "href": "https://doi.org/10.1016/j.archoralbio.2016.08.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27525378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27525378"}]}]}]}