{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐1270 (miR‑1270) has emerged as a multifunctional regulator in diverse biological contexts. In bladder cancer, for example, miR‑1270 is sponged by the circular RNA Cdr1as, thereby relieving its inhibition on apoptotic protease‑activating factor 1 (APAF1) and enhancing cisplatin‑induced chemosensitivity. Similarly, in papillary thyroid cancer its expression is under evaluation for potential mechanistic roles, and in kidney cells miR‑1270 binds in an allele‑specific manner within the 3′‑UTR of TAP2 to repress its expression and modulate antigen processing."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several malignancies miR‑1270 exhibits oncogenic features. In osteosarcoma, two independent studies report its aberrant upregulation in tumor tissues and cell lines, where higher miR‑1270 levels are associated with aggressive proliferation, migration, and poor patient outcomes, in part through targeting cingulin. In gastric cancer, elevated miR‑1270 correlates with advanced disease and reduced survival; here, the long noncoding RNA ASMTL‑AS1 appears to exert tumor‑suppressive effects by regulating miR‑1270. In esophageal cancer, the lncRNA SNHG8 sponges miR‑1270 to upregulate BACH1, thereby promoting tumor growth. Finally, in pancreatic cancer a circRNA (circ_0128846) sequesters miR‑1270 resulting in derepression of the glucocorticoid receptor NR3C1; silencing the circRNA enhances miR‑1270 action and dampens tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, miR‑1270 may also act as a tumor suppressor in other settings. In lung adenocarcinoma, two studies suggest divergent roles: one finds that up‑regulated lncRNA GLIDR sponges miR‑1270 leading to increased expression of its target TCF12, while another demonstrates that restoration of miR‑1270 suppresses RNA polymerase I transcription by downregulating core transcriptional components, thereby inhibiting proliferation, migration, and enhancing apoptosis. Beyond cancer, in preeclampsia reduced miR‑1270 in fetal endothelial colony‑forming cells is associated with ATM overexpression and subsequent endothelial dysfunction, highlighting its role in vascular biology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bridgett Knox, Yong Wang, Lora J Rogers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional SNP in the 3'-UTR of TAP2 gene interacts with microRNA hsa-miR-1270 to suppress the gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Mol Mutagen (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/em.22159"}], "href": "https://doi.org/10.1002/em.22159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29205500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29205500"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tongbo Yi, Xiaoqing Zhou, Kai Sang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1270 modulates papillary thyroid cancer cell development by regulating SCAI."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.08.150"}], "href": "https://doi.org/10.1016/j.biopha.2018.08.150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30551495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30551495"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenbo Yuan, Rui Zhou, Jingzi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA Cdr1as sensitizes bladder cancer to cisplatin by upregulating APAF1 expression through miR-1270 inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12523"}], "href": "https://doi.org/10.1002/1878-0261.12523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31131537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31131537"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lei Zhong, Changjun Zheng, Hongjuan Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1270 is associated with poor prognosis and its inhibition yielded anticancer mechanisms in human osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.1753"}], "href": "https://doi.org/10.1002/iub.1753"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29774985"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29774985"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yang Liu, Weichun Guo, Shuo Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1270 enhances the proliferation, migration, and invasion of osteosarcoma <em>via</em> targeting cingulin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Histochem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4081/ejh.2021.3237"}], "href": "https://doi.org/10.4081/ejh.2021.3237"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34873899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34873899"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhenhe Song, Jian Wang "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ASMTL-AS1/microRNA-1270 differentiate prognostic groups in gastric cancer and influence cell proliferation, migration and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2021063"}], "href": "https://doi.org/10.1080/21655979.2021.2021063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34986743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34986743"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yonghong Wu, Yan Liang, Min Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of long non-coding RNA SNHG8 suppresses the progression of esophageal cancer by regulating miR-1270/BACH1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2021064"}], "href": "https://doi.org/10.1080/21655979.2021.2021064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35067159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35067159"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ming Wang, Ming Li, Zehan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0128846 knockdown attenuates the progression of pancreatic cancer by targeting miR-1270/NR3C1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-28439-w"}], "href": "https://doi.org/10.1038/s41598-023-28439-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36797317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36797317"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Guigang Tai, Hongyi Fu, Hongzhong Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA GLIDR accelerates the tumorigenesis of lung adenocarcinoma by miR-1270/TCF12 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.1953754"}], "href": "https://doi.org/10.1080/15384101.2021.1953754"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34369267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34369267"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Bianca Schröder-Heurich, Tim Büder, Nadia Meyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of miR-1270 mediates endothelial progenitor cell function in preeclampsia: Role for ATM in the Src/VE-cadherin axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202200040RR"}], "href": "https://doi.org/10.1096/fj.202200040RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35648632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35648632"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Sheetanshu Saproo, Shashanka S Sarkar, Ekta Gupta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-330-5p and miR-1270 target essential components of RNA polymerase I transcription and exhibit a novel tumor suppressor role in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41417-022-00544-4"}], "href": "https://doi.org/10.1038/s41417-022-00544-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36253542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36253542"}]}]}]}