{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR-1271 functions as a tumor‐suppressive microRNA in hepatocellular carcinoma (HCC) by directly repressing key oncogenes. In HCC, miR-1271 is significantly downregulated and its re‐introduction inhibits cell growth and promotes cell death via a Glypican‑3 (GPC3)–dependent mechanism, suggesting that loss of miR‑1271 contributes to the aberrant overexpression of GPC3 during liver carcinogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in gastric cancer, reduced levels of miR‑1271 in cisplatin‐resistant cells correlate with upregulation of the insulin‐like growth factor 1 receptor (IGF1R)/insulin receptor substrate 1 (IRS1) signaling pathway, including downstream effectors mTOR and BCL2; enforced miR‑1271 expression in these cells restores chemosensitivity and curtails aberrant proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional investigations in HCC have demonstrated that miR‑1271 directly targets the oncogenic transcription factor FOXK2, such that restoration of miR‑1271 expression decreases FOXK2 mRNA and protein levels and consequently impairs tumor cell growth and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, studies in prostate cancer have shown that a circular RNA (circMBOAT2) can act as a molecular sponge for miR‑1271‑5p, thereby relieving suppression of mTOR and enhancing PI3K/Akt signaling—a pathway critical for cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " \n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marion Maurel, Sandra Jalvy, Yannick Ladeiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional screening identifies five microRNAs controlling glypican-3: role of miR-1271 down-regulation in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.25994"}], "href": "https://doi.org/10.1002/hep.25994"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22865282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22865282"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mifang Yang, Xia Shan, Xin Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1271 regulates cisplatin resistance of human gastric cancer cell lines by targeting IGF1R, IRS1, mTOR, and BCL2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Agents Med Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1871520614666140528161318"}], "href": "https://doi.org/10.2174/1871520614666140528161318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24875127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24875127"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mei-Fang Lin, Yu-Feng Yang, Zhen-Peng Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXK2, regulted by miR-1271-5p, promotes cell growth and indicates unfavorable prognosis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2017.05.019"}], "href": "https://doi.org/10.1016/j.biocel.2017.05.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28506857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28506857"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Juanyi Shi, Cheng Liu, Changhao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circMBOAT2 promotes prostate cancer progression via a miR-1271-5p/mTOR axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103432"}], "href": "https://doi.org/10.18632/aging.103432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32645691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32645691"}]}]}]}