{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have uncovered a tumor‐suppressive function of miR-1272 in prostate cancer, where its restoration in cancer cells reverts the mesenchymal phenotype, leading to reduced migration, invasion, and growth both in vitro and in vivo. Mechanistically, miR-1272 targets HIP1, an endocytic protein that modulates EGFR turnover and downstream AKT/ERK signaling, thereby also enhancing the tumor cells’ sensitivity to ionizing radiation. These findings suggest that therapeutic reconstitution of miR-1272 could potentially inhibit tumor progression and metastasis while improving radiotherapy outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn glioma, miR-1272 functions as a negative regulator of tumor progression. Overexpression of miR-1272 in glioma cell lines results in pronounced G0/G1 cell cycle arrest, leading to significant reductions in cell proliferation and migration. Here, ADAM9 was confirmed as a direct target of miR-1272, and its down-modulation subsequently influences the expression of CDCP1—another molecule implicated in the proliferative and migratory characteristics of glioma. The reversal of miR-1272’s inhibitory effects by restoring ADAM9 levels further reinforces the critical role of the miR-1272/ADAM9/CDCP1 axis in glioma pathology, making it a promising target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of hepatocellular carcinoma (HCC), alterations in miRNA expression patterns, including those of miR-1272, have been implicated in tumor pathogenesis. Although the precise role of miR-1272 in HCC remains to be fully elucidated, its involvement in other malignancies supports the notion that similar regulatory mechanisms may contribute to HCC development, particularly against a background of chronic liver disease and cirrhosis. Further investigation into miR-1272’s regulatory networks could provide novel insights into HCC pathogenesis and unveil new avenues for targeted therapies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Federica Rotundo, Denis Cominetti, Rihan El Bezawy, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "miR-1272"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Exerts Tumor-Suppressive Functions in Prostate Cancer via "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "HIP1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Suppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells9020435"}], "href": "https://doi.org/10.3390/cells9020435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32069895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32069895"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fei Geng, Gui-Feng Lu, Yu-Jun Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The emerging role of the MiR-1272-ADAM9-CDCP1 signaling pathway in the progression of glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202196"}], "href": "https://doi.org/10.18632/aging.202196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33260155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33260155"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zahra Asefy, Sirus Hoseinnejhad, Aziz Eftekhari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-515-3p, miR-623, miR-1272 and Notch3 protein as new biomarkers of Hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Horm Mol Biol Clin Investig (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/hmbci-2021-0019"}], "href": "https://doi.org/10.1515/hmbci-2021-0019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34954928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34954928"}]}]}]}