{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings indicate that MIR1273C may function as a molecular regulator linking energy metabolism to cellular activity. In the healthy brain, neurons are the primary site of glucose uptake – a process tightly coordinated with the activity‐dependent enrichment of metabolic enzymes such as hexokinases – suggesting that MIR1273C could modulate gene expression and/or enzyme localization to ensure that neuronal energy demands are met efficiently."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nUnder conditions of chronic stress, where adaptive changes in intracellular nutrient-sensing structures like mitochondria-associated membranes are critical for maintaining energy homoeostasis, MIR1273C is posited to participate in regulating the trafficking of key glycolytic enzymes – potentially safeguarding the coupling between systemic glucose availability and localized cellular metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, broad bioinformatics assessments in sepsis-induced acute lung injury have identified MIR1273C among candidate genes that may influence both inflammatory responses and metabolic dysregulation. This integrated role across diverse physiological and pathological states underscores the emerging view of MIR1273C as a putative post-transcriptional modulator capable of fine-tuning energy metabolism in response to dynamic cellular stress, a finding that invites further mechanistic studies and therapeutic exploration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Iben Lundgaard, Baoman Li, Lulu Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7807"}], "href": "https://doi.org/10.1038/ncomms7807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25904018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25904018"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Michael A van der Kooij, Liliana Rojas-Charry, Maryam Givehchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Med (Berl) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00109-022-02235-x"}], "href": "https://doi.org/10.1007/s00109-022-02235-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35943566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35943566"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mingyu Zhu, Xiaokai Tang, Jingjing Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of HK3 as a promising immunomodulatory and prognostic target in sepsis-induced acute lung injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2024.149759"}], "href": "https://doi.org/10.1016/j.bbrc.2024.149759"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38484574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38484574"}]}]}]}