{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‑1275 has emerged as a key regulatory molecule in cancer biology, exhibiting context‐dependent functions. In lung cancer, it acts as a tumor suppressor that is sponged by circMAN2B2, leading to enhanced FOXK1‐mediated proliferation and invasion (22736761."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, its ectopic expression downregulates multiple oncogenic IGF2BP proteins and IGF1R, thereby inhibiting malignant behavior. In glioblastoma and squamous cell carcinoma of the head and neck, alterations in miR‑1275 levels are associated with changes in tumor cell proliferation, differentiation, and epithelial‐mesenchymal transition (29102598, 29278769). Aberrant miR‑1275 activity has also been implicated in colorectal cancer, where reduced expression of the lncRNA HAND2‑AS1 fails to sufficiently sponge miR‑1275, resulting in repression of KLF14 and enhanced tumor progression, while studies in chronic myeloid leukemia hint at yet‑to‑be–characterized roles (29550475, 30078677, 30915755). Additionally, its genetic variants may interact with other risk alleles to modulate hepatocellular carcinoma susceptibility (31162799, 31357957, 32134323).\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its impact on tumorigenesis, miR‑1275 is involved in metabolic regulation. In adipose tissues, its downregulation in mature human visceral adipocytes and inverse correlation with body mass index suggest a role in adipocyte differentiation by targeting ELK1 (27154547."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, during the development of beige adipocytes from omental adipose‑derived stem cells, overexpression of miR‑1275 impedes the “browning” process by directly inhibiting the transcriptional regulator PRDM16. In the context of ischemic stroke, lower miR‑1275 levels correlate with atheroprotection via suppression of ApoC2 and attenuation of foam cell formation (31935511, 36128801).\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cardiovascular and therapeutic settings, miR‑1275 modulates cellular responses to stress and treatment. In esophageal cancer, reduced miR‑1275 levels promote radioresistance by facilitating epithelial–mesenchymal transition through derepression of WNT1 and activation of the Wnt/β‑catenin pathway (31733028). In breast cancer, diminished circulating miR‑1275 is linked to chemoresistance, partly by enhancing cancer stem cell properties through the MDK/AKT signaling axis, thereby predicting poorer overall survival (33323026, 33551225."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, in models of ischemia/reperfusion injury, upregulation of miR‑1275 aggravates myocardial damage, while its inhibition confers cellular protection via derepression of NMUR1, highlighting its potential as a therapeutic target in myocardial stress (31162799, 31733028, 33323026, 33551225, 36594100).\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Injie Omar Fawzy, Mohammed Tarif Hamza, Karim Adel Hosny, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1275: A single microRNA that targets the three IGF2-mRNA-binding proteins hindering tumor growth in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2015.06.038"}], "href": "https://doi.org/10.1016/j.febslet.2015.06.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26160756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26160756"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yu-Feng Zhou, Zi-Yi Fu, Xiao-Hui Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor necrosis factor‑α and interleukin‑6 suppress microRNA‑1275 transcription in human adipocytes through nuclear factor‑κB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7392"}], "href": "https://doi.org/10.3892/mmr.2017.7392"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28901460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28901460"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sevan Omer Majed, Suhad Asad Mustafa "}, {"type": "b", "children": [{"type": "t", "text": "MACE-Seq-based coding RNA and TrueQuant-based small RNA profile in breast cancer: tumor-suppressive miRNA-1275 identified as a novel marker."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-021-08218-4"}], "href": "https://doi.org/10.1186/s12885-021-08218-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33910530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33910530"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xu Han, Minghui Li, Jin Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1275 targets MDK/AKT signaling to inhibit breast cancer chemoresistance by lessening the properties of cancer stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.74227"}], "href": "https://doi.org/10.7150/ijbs.74227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36594100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36594100"}]}]}]}