{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have underscored the importance of non‐coding RNAs in the regulation of diverse cellular processes. For example, one investigation examined the critical role of the NF‐κB transcription factor in osteoclast differentiation, highlighting complex regulatory networks in cell fate decisions even though miR‐1276 was not directly addressed in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the field of cancer biology, miR‐1276 has emerged as an important regulatory microRNA that is functionally inactivated through sequestration by oncogenic circular RNAs. In bladder cancer, circ_0002623 is aberrantly upregulated and acts as a competing endogenous RNA by sponging miR‐1276, thereby relieving its inhibition on SMAD2. This cascade not only elevates SMAD2 expression but also modulates downstream TGF‐β and WNT1 signaling pathways to promote cell proliferation, migration, and cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in breast cancer, circOMA1 functions in an oncogenic manner by sponging miR‐1276, which results in the upregulation of SIRT4 and contributes to increased tumor cell viability, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional research into circular RNAs in other malignancies, such as gastric cancer, further exemplifies the elaborate nature of circRNA-mediated regulation in tumor progression, although a direct link to miR‐1276 was not delineated in these studies. Together, these findings suggest that miR‐1276 normally functions as a tumor‐suppressive microRNA, and its inactivation via sponging by specific circRNAs may represent a common mechanism contributing to cancer development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yandong Zhang, Chengyuan Ma, Chunshui Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-κB promotes osteoclast differentiation by overexpressing MITF via down regulating microRNA-1276 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2020.118093"}], "href": "https://doi.org/10.1016/j.lfs.2020.118093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32673666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32673666"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhaocun Zhang, Haifeng Zhao, Guanwen Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0002623 promotes bladder cancer progression by regulating the miR-1276/SMAD2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15274"}], "href": "https://doi.org/10.1111/cas.15274"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35048477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35048477"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lingli Xu, Ke Xu, Lijun Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR‑1276/SIRT4 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.12367"}], "href": "https://doi.org/10.3892/mmr.2021.12367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34414449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34414449"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xueguang Dong, Xiumei Chen, Yuanhao Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircTMEM87A promotes the tumorigenesis of gastric cancer by regulating the miR-1276/SLC7A11 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol Hepatol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jgh.16402"}], "href": "https://doi.org/10.1111/jgh.16402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38037531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38037531"}]}]}]}