{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR‐1277‐5p functions as an important regulatory hub in diverse pathological conditions by modulating key target genes through competing endogenous RNA (ceRNA) networks. In osteoarthritis, miR‐1277‐5p normally suppresses the expression of matrix metalloproteinase‐13 (MMP13) and ADAMTS5, two proteins implicated in extracellular matrix degradation; however, its activity is attenuated by the long noncoding RNA XIST, which acts as a ceRNA, thereby promoting ECM breakdown. Similarly, in a Parkinson’s disease model, miR‐1277‐5p is sequestered by the lncRNA NEAT1, resulting in upregulation of ARHGAP26 and subsequent enhancement of apoptosis, inflammation, and oxidative stress in dopaminergic cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in neurodegeneration and joint pathology, miR‐1277‐5p has been implicated in cardiovascular pathology and malignancy. In carotid atherosclerosis, the lncRNA LINC01123 acts as a sponge for miR‐1277‐5p, thereby diminishing its inhibitory effect on KLF5, which in turn augments vascular smooth muscle cell proliferation and migration and may promote fibrotic plaque formation. Furthermore, in glioma, miR‐1277‐5p is targeted by LINC01087; under normal conditions miR‐1277‐5p suppresses the expression of ACER3, an enzyme associated with tumor progression, and downregulation of miR‐1277‐5p through aberrant lncRNA sponging contributes to a more aggressive glioma phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tao Wang, Yize Liu, Yong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA XIST promotes extracellular matrix degradation by functioning as a competing endogenous RNA of miR-1277-5p in osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2019.4240"}], "href": "https://doi.org/10.3892/ijmm.2019.4240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31198977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31198977"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shufang Zhou, Dan Zhang, Junnan Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of NEAT1 prevented MPP"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-induced inflammatory response, oxidative stress and apoptosis in dopaminergic SK-N-SH neuroblastoma cells via miR-1277-5p/ARHGAP26 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2020.147156"}], "href": "https://doi.org/10.1016/j.brainres.2020.147156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33069733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33069733"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Guohu Weng, Minhua Gu, Yifan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01123 promotes cell proliferation and migration via regulating miR-1277-5p/KLF5 axis in ox-LDL-induced vascular smooth muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Histol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10735-021-10010-4"}], "href": "https://doi.org/10.1007/s10735-021-10010-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34403009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34403009"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wangsheng Chen, Fei Wang, Jianhua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01087 indicates a poor prognosis of glioma patients with preoperative MRI."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Funct Integr Genomics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10142-021-00812-w"}], "href": "https://doi.org/10.1007/s10142-021-00812-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34817752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34817752"}]}]}]}