| HGNC Family | Non-coding RNAs |
| Name | microRNA 1279 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe microRNA MIR1279 exhibits a conserved regulatory function by binding to the coding sequences of specific mRNAs. Notably, it targets the transcripts of PTPN12, MSH6, and ZEB1, where its binding sites encode the oligopeptides TKEQYE, EGSSDE, and GEKPYE, respectively. This unusual targeting within the CDS and the presence of evolutionarily conserved binding sites among orthologs and numerous paralogs—such as the multiple sites in zinc finger gene family members—suggest a role for MIR1279 in fine‐tuning protein synthesis and maintaining peptide sequence integrity across species."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \n \nIn addition, genetic variability in and around the MIR1279 gene appears to modulate disease risk. A polymorphism (rs1463335) located upstream of MIR1279 was found to influence the expression of TRAF3IP2, linking MIR1279 to the susceptibility of systemic lupus erythematosus (SLE) complications, particularly pericarditis. The association of this MIR1279 variant with pericarditis, especially when considered in combination with risk alleles from other genes such as STAT4, PTPN2, and TRAF3IP2, underscores its potential utility in risk profiling and the management of SLE patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anatoliy T Ivashchenko, Assel S Issabekova, Olga A Berillo "}, {"type": "b", "children": [{"type": "t", "text": "miR-1279, miR-548j, miR-548m, and miR-548d-5p binding sites in CDSs of paralogous and orthologous PTPN12, MSH6, and ZEB1 Genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2013/902467"}], "href": "https://doi.org/10.1155/2013/902467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23957009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23957009"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "C Ciccacci, C Perricone, C Politi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A polymorphism upstream MIR1279 gene is associated with pericarditis development in Systemic Lupus Erythematosus and contributes to definition of a genetic risk profile for this complication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lupus (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0961203316679528"}], "href": "https://doi.org/10.1177/0961203316679528"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27879428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27879428"}]}]}]}
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| Synonyms | HSA-MIR-1279, MIRN1279 |
| NCBI Gene ID | 100302182 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR1279 has 364 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.
Click the + buttons to view associations for MIR1279 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR1279 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1279 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of MIR1279 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR1279 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR1279 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1279 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIR1279 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with MIR1279 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MIR1279 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR1279 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of MIR1279 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of MIR1279 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MIR1279 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR1279 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
