MIR1281 Gene

HGNC Family Non-coding RNAs
Name microRNA 1281
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In malignant pleural mesothelioma, miR‑1281 is significantly upregulated in patient sera compared to healthy subjects and workers previously exposed to asbestos, suggesting its diagnostic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In oropharyngeal squamous‐cell carcinoma, high expression of miR‑1281 in both HPV‑associated and non‑HPV metastases has been linked to increased migratory cancer stem cell populations, underscoring its possible role in promoting metastatic progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in the context of diabetic retinopathy, miR‑1281 was found to be the most upregulated circulating microRNA and appears to be functionally related to high‐glucose exposure in retinal cells, further supporting its utility as a predictive biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role as a biomarker, miR‑1281 acts as a key regulatory molecule in tumor progression by targeting genes that control cell proliferation and invasion. In glioma, for instance, the oncogenic long noncoding RNA LINC01857 sponges miR‑1281, leading to the upregulation of TRIM65 and enhanced tumor cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " A similar regulatory axis is observed in colorectal cancer, where LINC00963 binds and represses miR‑1281, resulting in increased TRIM65 levels and heightened malignant behaviors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In glioma as well, circ_0001588 functions as an oncogene by interacting with miR‑1281 and modulating ERBB4 expression, thereby promoting tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its oncogenic and biomarker roles, miR‑1281 exerts cytoprotective effects in infectious disease models. In human macrophages infected with Mycobacterium tuberculosis, miR‑1281 directly targets cyclophilin‑D; its ectopic overexpression reduces the activity of the CypD 3′‑untranslated region, leading to lower CypD expression and protection against MTB‑induced programmed necrosis and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ilaria Bononi, Manola Comar, Andrea Puozzo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating microRNAs found dysregulated in ex-exposed asbestos workers and pleural mesothelioma patients as potential new biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12408"}], "href": "https://doi.org/10.18632/oncotarget.12408"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27716620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27716620"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Martin Hufbauer, Margaret Maltseva, Jeannine Meinrath, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HPV16 increases the number of migratory cancer stem cells and modulates their miRNA expression profile in oropharyngeal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.31538"}], "href": "https://doi.org/10.1002/ijc.31538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29663357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29663357"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marta Greco, Eusebio Chiefari, Francesca Accattato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1281 as a Novel Circulating Biomarker in Patients With Diabetic Retinopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Endocrinol (Lausanne) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fendo.2020.00528"}], "href": "https://doi.org/10.3389/fendo.2020.00528"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32849308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32849308"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Guozhang Hu, Naijie Liu, Han Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC01857 promotes growth, migration, and invasion of glioma by modulating miR-1281/TRIM65 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28763"}], "href": "https://doi.org/10.1002/jcp.28763"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31049960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31049960"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Haidong Lv, Dixia Zhou, Guoqing Liu "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00963 promotes colorectal cancer cell proliferation and metastasis by regulating miR‑1281 and TRIM65."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.12421"}], "href": "https://doi.org/10.3892/mmr.2021.12421"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34498706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34498706"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jun Wang, Juan Li, Peng Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0001588 Upregulates ERBB4 to Promote Glioma Malignant Progression Through Sponging miR-1281."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurotox Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12640-021-00464-5"}], "href": "https://doi.org/10.1007/s12640-021-00464-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34982356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34982356"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Qin Sun, Xiaona Shen, Peng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting cyclophilin-D by miR-1281 protects human macrophages from "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Mycobacterium tuberculosis"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-induced programmed necrosis and apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102593"}], "href": "https://doi.org/10.18632/aging.102593"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31884421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31884421"}]}]}]}
Synonyms MIRN1281, HSA-MIR-1281
NCBI Gene ID 100302237
API
Download Associations
Predicted Functions View MIR1281's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1281's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1281's ARCHS4 Predicted Functions.

Functional Associations

MIR1281 has 1,339 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR1281 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1281 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1281 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1281 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1281 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1281 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1281 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1281 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR1281 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1281 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1281 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR1281 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR1281 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1281 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of MIR1281 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1281 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.