MIR1284 Gene

HGNC Family Non-coding RNAs
Name microRNA 1284
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that microRNA‐1284 functions as a tumor suppressor in several cancer types by modulating cell proliferation, migration, invasion, and chemosensitivity. In gastric cancer, miR‐1284 is downregulated in tissues with metastasis and in vincristine‐resistant cells; its overexpression reverses chemoresistance by inducing G0/G1 cell cycle arrest, accelerating apoptosis, and reducing migratory and invasive behaviors. These effects are mediated through the suppression of targets such as EIF4A1, as well as modulation of oncogenes including MYC, JUN, and MMP12."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn lung cancer, enforced expression of miR‐1284 decreases cell viability and growth, elevates p27 levels, reduces Myc expression, and activates apoptotic pathways, thereby curbing tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Likewise, in osteosarcoma, miR‐1284 levels are lower in tumor tissues compared with adjacent normal tissues, and its overexpression inhibits cell proliferation and migration by directly targeting HMGB1 and altering epithelial–mesenchymal transition markers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn breast cancer, miR‐1284 is similarly downregulated relative to normal tissues; its upregulation suppresses proliferation, migration, and invasion, and promotes apoptosis by targeting the transcription factor ZIC2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In cervical cancer, investigation into its role in cisplatin sensitivity suggests that miR‐1284 may enhance the effectiveness of chemotherapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In thyroid cancer, although miR‐1284 is reduced in tumor tissues, its elevated levels in patient peripheral blood—likely secreted via exosomes—correlate with reduced cellular proliferation and migration and increased apoptosis, alongside modulation of EMT‐related proteins (increased E‐cadherin and decreased N‐cadherin)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenlong Cao, Weiyuan Wei, Zexu Zhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.4643"}], "href": "https://doi.org/10.3892/or.2016.4643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26936591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26936591"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jie Li, Hairong Jin, Hua Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA‑1284 inhibits cell growth and induces apoptosis of lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.6949"}], "href": "https://doi.org/10.3892/mmr.2017.6949"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28713980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28713980"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shuai Lv, Meng Guan "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-1284, a regulator of HMGB1, inhibits cell proliferation and migration in osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20171675"}], "href": "https://doi.org/10.1042/BSR20171675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29899164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29899164"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Pengcheng Zhang, Fang Yang, Qin Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1284 Inhibits the Growth and Invasion of Breast Cancer Cells by Targeting ZIC2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504018X15242763477504"}], "href": "https://doi.org/10.3727/096504018X15242763477504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30075825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30075825"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jia Chen, Gaojun Li "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1284 enhances sensitivity of cervical cancer cells to cisplatin via downregulating HMGB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.08.059"}], "href": "https://doi.org/10.1016/j.biopha.2018.08.059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30257412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30257412"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lingjie Zhang, Rui Ge, Aiqun Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-1284 suppresses the proliferation and migration of thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14715/cmb/2023.69.8.38"}], "href": "https://doi.org/10.14715/cmb/2023.69.8.38"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37715373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37715373"}]}]}]}
Synonyms MIRN1284, MIR-1284, HSA-MIR-1284
NCBI Gene ID 100302112
API
Download Associations
Predicted Functions View MIR1284's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1284's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1284's ARCHS4 Predicted Functions.

Functional Associations

MIR1284 has 584 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR1284 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1284 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1284 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1284 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1284 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1284 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1284 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1284 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR1284 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR1284 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1284 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1284 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR1284 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1284 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1284 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.