{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nResearch across diverse pathological contexts indicates that MIR1285‐2, a member of the miR‐1285 family, functions predominantly as a tumor suppressor. For instance, in lung squamous cell carcinoma, comprehensive miRNA profiling identified differentially expressed miRNAs that hold promise as early biomarkers, suggesting a potential role for MIR1285‐2 in early detection and outcome prediction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In pancreatic ductal adenocarcinoma, downregulation of miR‐1285 is associated with enhanced cell proliferation and chemoresistance; restoration of its levels suppressed oncogenic signals—including YAP1, EGFR, and β‐catenin—and increased gemcitabine sensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in breast cancer, lower expression of miR‐1285‐5p correlates with poor prognosis; overexpression inhibited cell proliferation, and mechanistic studies revealed that miR‐1285–mediated suppression of targets such as TMEM194A disrupts centrosome dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Further extending its role in oncogenesis, network analyses have implicated a circular RNA (hsa_circ_0000376) acting as a sponge for miR‐1285‐3p, thereby modulating the expression of genes like SMURF1, BTRC, and TP53 involved in cell cycle and apoptosis regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its involvement in cancer, MIR1285‐2 appears to play critical roles in other disease states. In type 2 diabetes, miR‐1285 has emerged as a novel prognostic, diagnostic, and therapeutic target, with its modulation potentially affecting key cellular processes and signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Additionally, in ocular pathology, particularly in a rabbit model of proliferative vitreoretinopathy, overexpression of miR‐1285 counteracted TGF‐β2–induced epithelial–mesenchymal transition (EMT) by directly targeting Smad4, thereby alleviating EMT features such as aberrant cell migration and contractility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these studies underscore the multifaceted role of MIR1285‐2 in regulating cellular proliferation, motility, and response to injury, highlighting its potential as both a biomarker and a therapeutic target in a range of pathological settings.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xujie Gao, Yang Wang, Hua Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma miR-324-3p and miR-1285 as diagnostic and prognostic biomarkers for early stage lung squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.11198"}], "href": "https://doi.org/10.18632/oncotarget.11198"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27517633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27517633"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "H Huang, G Xiong, P Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1285 inhibits malignant biological behaviors of human pancreatic cancer cells by negative regulation of YAP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2017_306"}], "href": "https://doi.org/10.4149/neo_2017_306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28253715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28253715"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ai Hironaka-Mitsuhashi, Kurataka Otsuka, Luc Gailhouste, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Methylation dependent microRNA 1285-5p and sterol carrier proteins 2 in type 2 diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21691401.2019.1652625"}], "href": "https://doi.org/10.1080/21691401.2019.1652625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31407919"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31407919"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shu-I Pao, Le-Tien Lin, Yi-Hao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Repression of Smad4 by MicroRNA-1285 moderates TGF-β-induced epithelial-mesenchymal transition in proliferative vitreoretinopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0254873"}], "href": "https://doi.org/10.1371/journal.pone.0254873"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34383767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34383767"}]}]}]}