MIR1286 Gene

HGNC Family Non-coding RNAs
Name microRNA 1286
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐1286 has been implicated in the regulation of osteogenic differentiation. In human marrow mesenchymal stem cells, miR‐1286 inhibits osteogenic differentiation by targeting FZD4 expression, thereby promoting osteoporotic progression. This finding suggests that miR‐1286 functions as a negative regulator of bone formation, potentially contributing to bone density loss when overexpressed or dysregulated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of gastric cancer, miR‐1286 is sequestered by specific circular RNAs. For instance, circCOL1A2 acts as a competing endogenous RNA that sponges miR‐1286, relieving its suppression on USP10. The de‐repressed USP10 then decreases the ubiquitination level of RFC2, which in turn enhances cell migration and invasion. This mechanism highlights a tumor‐promoting role for the circCOL1A2/miR‐1286/USP10 regulatory axis by functionally impairing the inhibitory role of miR‐1286 on oncogenic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in osteosarcoma, long non‐coding RNAs modulate tumor progression via the sponging of miR‐1286. HOXA‐AS3, for example, acts as a competing endogenous RNA that directly targets and reduces miR‐1286 availability, leading to the upregulation of TEAD1 expression. The consequent overexpression of TEAD1 correlates with enhanced proliferation, migration, invasion, and epithelial–mesenchymal transition in osteosarcoma cells, underscoring the potent oncogenic impact of impaired miR‐1286 function in this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J-G Zhou, Y Hua, S-W Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1286 inhibits osteogenic differentiation of mesenchymal stem cells to promote the progression of osteoporosis via regulating FZD4 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202001_19889"}], "href": "https://doi.org/10.26355/eurrev_202001_19889"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31957812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31957812"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hang Li, Lixin Chai, Zujun Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircCOL1A2 Sponges MiR-1286 to Promote Cell Invasion and Migration of Gastric Cancer by Elevating Expression of USP10 to Downregulate RFC2 Ubiquitination Level."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Microbiol Biotechnol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4014/jmb.2112.12044"}], "href": "https://doi.org/10.4014/jmb.2112.12044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35791074"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35791074"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiangjun Xiao, Mingjiang Liu, Songlin Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding HOXA-AS3 contributes to osteosarcoma progression through the miR-1286/TEAD1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Surg Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13018-023-04214-5"}], "href": "https://doi.org/10.1186/s13018-023-04214-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37752588"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37752588"}]}]}]}
Synonyms MIR-1286, HSA-MIR-1286, MIRN1286
NCBI Gene ID 100302118
API
Download Associations
Predicted Functions View MIR1286's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1286's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1286's ARCHS4 Predicted Functions.

Functional Associations

MIR1286 has 383 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR1286 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1286 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1286 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1286 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1286 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1286 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1286 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1286 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR1286 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1286 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1286 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1286 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1286 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.