MIR1287 Gene

HGNC Family Non-coding RNAs
Name microRNA 1287
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐1287 (miR‐1287), including its mature isoform miR‐1287‐5p, has emerged as an important tumor‐suppressive regulator in several cancer types. In early laryngeal carcinoma, for example, miR‐1287 is significantly downregulated relative to normal mucosa, suggesting its potential as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In non‐small cell lung cancer (NSCLC), overexpression of a circular RNA, circ_0016760, sponges miR‐1287, thereby relieving its inhibitory control over oncogenic targets such as GAGE1 and promoting tumor proliferation and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies have highlighted that deregulation of miR‐1287‐5p contributes to tumor progression in a variety of malignancies. In retinoblastoma, for instance, oncogenic circRNA (circ_0099198) sequesters miR‐1287, leading to the upregulation of LRP6 and enhancing tumor cell growth and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In hepatocellular carcinoma, miR‐1287‐5p is similarly targeted by circ_CCT3, which promotes TEAD1‐mediated gene transcription and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Furthermore, evidence from cervical cancer and hepatitis B virus–associated infection suggests a broader suppressive role for miR‐1287‐5p in oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In osteosarcoma, the restoration of miR‐1287‐5p levels was shown to trigger ferroptosis via the direct inhibition of glutathione peroxidase 4 (GPX4), thereby decreasing cell viability and enhancing sensitivity to chemotherapeutic agents."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, in NSCLC cells, a separate circular RNA (circ_0008717) sequesters miR‐1287‐5p to upregulate PAK2, thus further contributing to tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond solid tumors, miR‐1287‐5p appears critical in hematologic malignancies and inflammatory vascular disorders. In acute myeloid leukemia (AML), miR‐1287‐5p is downregulated, and its upregulation through circ_0059707 overexpression inhibits leukemic cell growth and promotes apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In microscopic polyangiitis, exosomal transfer of miR‐1287‐5p and its subsequent targeting of the E3 ubiquitin ligase CBL are implicated in modulating vascular endothelial injury in the inflammatory microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In papillary thyroid carcinoma, miR‐1287‐5p is sponged by circPI4KA, leading to the upregulation of Neuropilin‐2 (NRP2) and contributing to tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan Wang, Mingtao Chen, Zezhang Tao, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Upregulated circular RNA circ_0016760 indicates unfavorable prognosis in NSCLC and promotes cell progression through miR-1287/GAGE1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.07.164"}], "href": "https://doi.org/10.1016/j.bbrc.2018.07.164"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30103946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30103946"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yanhua Jiang, Fan Xiao, Lin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0099198 facilitates the progression of retinoblastoma by regulating miR-1287/LRP6 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Eye Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exer.2021.108529"}], "href": "https://doi.org/10.1016/j.exer.2021.108529"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33676964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33676964"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wennan Lin, Tianyu Zhang, Guoxu Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circ‑CCT3 promotes hepatocellular carcinoma progression by regulating the miR‑1287‑5p/TEAD1/PTCH1/LOX axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.12014"}], "href": "https://doi.org/10.3892/mmr.2021.12014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33760147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33760147"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wenwei Hao, Yongping Zhu, Ying Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1287-5p upregulation inhibits the EMT and pro-inflammatory cytokines in LPS-induced human nasal epithelial cells (HNECs)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transpl Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.trim.2021.101429"}], "href": "https://doi.org/10.1016/j.trim.2021.101429"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34139308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34139308"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhengquan Xu, Lanhua Chen, Changsheng Wang, et al. 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Synonyms MIR-1287, HSA-MIR-1287, MIRN1287
NCBI Gene ID 100302133
API
Download Associations
Predicted Functions View MIR1287's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1287's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1287's ARCHS4 Predicted Functions.

Functional Associations

MIR1287 has 392 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.

Click the + buttons to view associations for MIR1287 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1287 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1287 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1287 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1287 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1287 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1287 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR1287 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of MIR1287 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR1287 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1287 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1287 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1287 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1287 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.