{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn colorectal cancer, miR‑1288 appears to play a significant role in regulating cell proliferation and cell cycle progression. In colon cancer cell lines, reduced endogenous levels of miR‑1288 were observed compared to normal colonic epithelial cells, yet forced overexpression of miR‑1288 led to increased proliferation and a greater fraction of cells in the G2–M phase. These findings indicate that alterations in miR‑1288 expression may be critical in the progression and staging of colorectal tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn other cancer types, miR‑1288 is also implicated in promoting tumor cell growth. In glioblastoma, miR‑1288 is markedly upregulated, and its ectopic expression enhances cell proliferation, colony formation, and anchorage‑independent growth by targeting the tumor suppressor CYLD. In oesophageal squamous cell carcinoma, studies are examining how alterations in miR‑1288 expression affect cellular behavior and target interactions, further suggesting its involvement in oncogenic signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in cancer proliferation, miR‑1288 also has important implications in non‐malignant conditions. In a genetic study of schizophrenia, a specific 3′‑UTR variant (rs7219) in the GRB2 gene was found to generate a binding site for miR‑1288, with the minor allele leading to reduced GRB2 expression and an increased risk of developing the disorder. Moreover, investigations in oral squamous cell carcinoma have highlighted a regulatory axis in which a circular RNA (hsa_circ_0096042) sponges miR‑1288, thereby modulating the expression of the tumor suppressor KRT4 and ultimately influencing tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Vinod Gopalan, Suja Pillai, Faeza Ebrahimi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of microRNA-1288 in colorectal cancer: altered expression and its clinicopathological significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.21993"}], "href": "https://doi.org/10.1002/mc.21993"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24009195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24009195"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Vinod Gopalan, Farhadul Islam, Suja Pillai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of microRNA-1288 in oesophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2016.09.010"}], "href": "https://doi.org/10.1016/j.yexcr.2016.09.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27658568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27658568"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jun Yin, Chengyin Weng, Jieke Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑1288 promotes cell proliferation of human glioblastoma cells by repressing ubiquitin carboxyl‑terminal hydrolase CYLD expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7481"}], "href": "https://doi.org/10.3892/mmr.2017.7481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28901464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28901464"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jialei Yang, Xiaojing Guo, Lulu Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rs7219 Regulates the Expression of GRB2 by Affecting miR-1288-Mediated Inhibition and Contributes to the Risk of Schizophrenia in the Chinese Han Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Neurobiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10571-018-0639-9"}], "href": "https://doi.org/10.1007/s10571-018-0639-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30474799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30474799"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lu Wang, Xin Ma, Jie Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Negative regulation of miR-1288-3p/KRT4 axis through a circular RNA in oral cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.23118"}], "href": "https://doi.org/10.1002/jbt.23118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35707935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35707935"}]}]}]}