{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe MIR129 family—including miR‐129‑1‑3p and miR‐129‑5p isoforms—has emerged as a robust tumor suppressor in a wide array of human cancers. Many studies report that in bladder, colorectal, gastric, hepatocellular, medullary thyroid and pancreatic carcinomas, MIR129 expression is frequently down‐regulated (often via epigenetic silencing), which contributes to unchecked cell proliferation, resistance to apoptosis and aberrant cell cycle progression. Restoration of MIR129 levels leads to marked growth inhibition, induction of G₀/G₁ cell cycle arrest and increased cell death via its direct targeting of key oncogenic drivers including anti‐apoptotic BCL2, cyclin‐dependent kinases and transcription factors such as SOX4, PAK5, RET and PBX3."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMIR129’s function is further fine‐tuned by its interactions with non‐coding RNAs that act as molecular sponges. Long non‑coding RNAs (lncRNAs) such as MALAT1, RP11‑89, UCA1, TNRC6C‑AS1, DLX6‑AS1, OIP5‑AS1 and DARS‑AS1—and certain circular RNAs like circ_0007841—sequester MIR129, thereby diminishing its bioavailability. This de‐repression of downstream targets (for example, HMGB1, PROM2, key ABC transporters and SOX2) has been linked to increased chemoresistance and metastatic potential in malignancies including bladder, gastric, papillary thyroid, ovarian and breast cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to controlling cell proliferation and survival, MIR129 plays a central role in restraining cell migration, invasion and the epithelial‐to‐mesenchymal transition (EMT) as well as in modulating autophagic processes. By directly targeting molecules involved in centrosomal function (e.g. CP110), cytoskeletal dynamics (e.g. through Twist1 and the bradykinin receptor B2), inflammation (e.g. IL‑8) and oncogenic transcription (via suppression of YAP/TAZ activity), MIR129 contributes to reduced metastasis and drug resistance. 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"}, {"type": "b", "children": [{"type": "t", "text": "MALAT1 promotes osteosarcoma development by regulation of HMGB1 via miR-142-3p and miR-129-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2017.1288324"}], "href": "https://doi.org/10.1080/15384101.2017.1288324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28346809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28346809"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Stephanie Rebecca Setijono, Mikyung Park, Goeun Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-218 and miR-129 regulate breast cancer progression by targeting Lamins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.01.146"}], "href": "https://doi.org/10.1016/j.bbrc.2018.01.146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29378184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29378184"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jianwen Long, Qiqige Menggen, Qimige Wuren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA Taurine-Upregulated Gene1 (TUG1) Promotes Tumor Growth and Metastasis Through TUG1/Mir-129-5p/Astrocyte-Elevated Gene-1 (AEG-1) Axis in Malignant Melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/msm.906616"}], "href": "https://doi.org/10.12659/msm.906616"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29543785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29543785"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Junrong Wang, Cong Ye, Junbao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UCA1 confers paclitaxel resistance to ovarian cancer through miR-129/ABCB1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.05.104"}], "href": "https://doi.org/10.1016/j.bbrc.2018.05.104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29777711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29777711"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sen Hou, Qiuyu Lin, Feng Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA TNRC6C-AS1 regulates UNC5B in thyroid cancer to influence cell proliferation, migration, and invasion as a competing endogenous RNA of miR-129-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26868"}], "href": "https://doi.org/10.1002/jcb.26868"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29893424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29893424"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jingyi Cao, Qichao Wang, Gang Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-129-5p inhibits gemcitabine resistance and promotes cell apoptosis of bladder cancer cells by targeting Wnt5a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Urol Nephrol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11255-018-1959-x"}], "href": "https://doi.org/10.1007/s11255-018-1959-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30117016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30117016"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Rong-Mou Zhang, Ting Tang, Hai-Ming Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA DLX6-AS1/miR-129-5p/DLK1 axis aggravates stemness of osteosarcoma through Wnt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.11.019"}], "href": "https://doi.org/10.1016/j.bbrc.2018.11.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30442366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30442366"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Huijuan Zeng, Jingjie Wang, Tao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of long non-coding RNA Opa interacting protein 5-antisense RNA 1 inhibits breast cancer progression by targeting sex-determining region Y-box 2 by microRNA-129-5p upregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.13879"}], "href": "https://doi.org/10.1111/cas.13879"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30443959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30443959"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "W Zheng, X Tian, L Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA DARS-AS1 regulates microRNA-129 to promote malignant progression of thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201912_19683"}], "href": "https://doi.org/10.26355/eurrev_201912_19683"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31841198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31841198"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yan Wang, Quande Lin, Chunge Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Depletion of circ_0007841 inhibits multiple myeloma development and BTZ resistance via miR-129-5p/JAG1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2020.1839701"}], "href": "https://doi.org/10.1080/15384101.2020.1839701"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33131409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33131409"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jingli Cao, Yidong Shen, Lei Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2512"}], "href": "https://doi.org/10.1038/ncb2512"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22684256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22684256"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jiarong Zhang, Shuangdi Li, Qin Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon-β induced microRNA-129-5p down-regulates HPV-18 E6 and E7 viral gene expression by targeting SP1 in cervical cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0081366"}], "href": "https://doi.org/10.1371/journal.pone.0081366"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24358111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24358111"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Danping Wang, Lin Luo, Junming Guo "}, {"type": "b", "children": [{"type": "t", "text": "miR-129-1-3p inhibits cell migration by targeting BDKRB2 in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-014-0098-1"}], "href": "https://doi.org/10.1007/s12032-014-0098-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25008064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25008064"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Guosheng Tan, Xinping Cao, Qiangsheng Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3254"}], "href": "https://doi.org/10.18632/oncotarget.3254"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25895125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25895125"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yue Yu, Ying Zhao, Xiao-Hu Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.5406"}], "href": "https://doi.org/10.18632/oncotarget.5406"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26460733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26460733"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yuan Zhang, Yu Wang, Yifang Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-129-3p promotes docetaxel resistance of breast cancer cells via CP110 inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep15424"}], "href": "https://doi.org/10.1038/srep15424"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26487539"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26487539"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Fatemeh Kouhkan, Naser Mobarra, Mina Soufi-Zomorrod, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-129-1 acts as tumour suppressor and induces cell cycle arrest of GBM cancer cells through targeting IGF2BP3 and MAPK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2015-103225"}], "href": "https://doi.org/10.1136/jmedgenet-2015-103225"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26510428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26510428"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Z Jiang, H Wang, Y Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-129-5p is down-regulated and involved in migration and invasion of gastric cancer cells by targeting interleukin-8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2016_503"}], "href": "https://doi.org/10.4149/neo_2016_503"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27468870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27468870"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Weijian Sun, Yongdong Yi, Guojun Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nrf2-miR-129-3p-mTOR Axis Controls an miRNA Regulatory Network Involved in HDACi-Induced Autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymthe.2019.02.010"}], "href": "https://doi.org/10.1016/j.ymthe.2019.02.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30852137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30852137"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Xing Yu, Lin Luo, Yibo Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gastric juice miR-129 as a potential biomarker for screening gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-012-0365-y"}], "href": "https://doi.org/10.1007/s12032-012-0365-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23307240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23307240"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Yanping Gao, Bing Feng, Siqi Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-129 in Human Cancers: from Tumorigenesis to Clinical Treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000447913"}], "href": "https://doi.org/10.1159/000447913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27802440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27802440"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Yonggang Zuo, Yue Li, Zhenyu Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA MALAT1 promotes proliferation and invasion via targeting miR-129-5p in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.09.005"}], "href": "https://doi.org/10.1016/j.biopha.2017.09.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28915533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28915533"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Yinghua Chen, Yitao Ou, Jiale Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteopontin promotes collagen I synthesis in hepatic stellate cells by miRNA-129-5p inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2017.11.035"}], "href": "https://doi.org/10.1016/j.yexcr.2017.11.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29196165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29196165"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Hong Zhang, Yuechang Cai, Li Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA NEAT1 regulate papillary thyroid cancer progression by modulating miR-129-5p/KLK7 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.26425"}], "href": "https://doi.org/10.1002/jcp.26425"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29319165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29319165"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "D-Z Fang, Y-P Wang, J Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-129-3p suppresses tumor growth by targeting E2F5 in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201802_14387"}], "href": "https://doi.org/10.26355/eurrev_201802_14387"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29509253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29509253"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Qi Liu, Jianwu Jiang, Yang Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-129-5p functions as a tumor suppressor in gastric cancer progression through targeting ADAM9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.05.105"}], "href": "https://doi.org/10.1016/j.biopha.2018.05.105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29879625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29879625"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Olfat G Shaker, Mostafa Y Abdelwahed, Naglaa A Ahmed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evaluation of serum long noncoding RNA NEAT and MiR-129-5p in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.2096"}], "href": "https://doi.org/10.1002/iub.2096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31190421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31190421"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Yi Wan, Zhi-Quan Yang "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA NEAT1 affects inflammatory response by targeting miR-129-5p and regulating Notch signaling pathway in epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2020.1711578"}], "href": "https://doi.org/10.1080/15384101.2020.1711578"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31948324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31948324"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Min Qiu, Da Liu, Qin Fu "}, {"type": "b", "children": [{"type": "t", "text": "MiR-129-5p shuttled by human synovial mesenchymal stem cell-derived exosomes relieves IL-1β induced osteoarthritis via targeting HMGB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2020.118987"}], "href": "https://doi.org/10.1016/j.lfs.2020.118987"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33417958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33417958"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Zhanqin Zhang, Hongtao Zhu, Jianguo Hu "}, {"type": "b", "children": [{"type": "t", "text": "CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03486-1"}], "href": "https://doi.org/10.1038/s41419-021-03486-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33637694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33637694"}]}]}]}