{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRenal cell carcinoma (RCC) is a highly aggressive malignancy, and recent studies have implicated the dysregulation of non‐coding RNAs in its progression. In clear cell RCC, a decreased expression of the circular RNA circ‑IP6K2 has been observed, which is clinically associated with advanced tumor stage, higher histological grade, and poorer overall survival. Mechanistic investigations revealed that circ‑IP6K2 normally functions as a molecular sponge for miR‑1292‑5p, thereby curtailing its availability to influence downstream targets."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nmiR‑1292‑5p, when not sequestered by circ‑IP6K2, binds to the 3′ untranslated region of CAMK2N1 mRNA, leading to its downregulation. CAMK2N1 acts as a tumor suppressor by inhibiting the oncogenic β‑catenin/c‑Myc signaling pathway; thus, elevated miR‑1292‑5p activity contributes to enhanced tumor cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTogether, these findings underscore the critical role of miR‑1292‑5p in ccRCC pathogenesis, highlighting that the loss of circ‑IP6K2’s sponging capacity leads to unchecked miR‑1292‑5p activity and suppression of a key tumor suppressor. This miR‑1292‑5p/CAMK2N1 regulatory axis represents a promising avenue for therapeutic intervention in ccRCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jian-Ying Tang, Lu Yang, Qing-Jian Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ-IP6K2 suppresses tumor progression by modulating the miR-1292-5p/CAMK2N1 signal in clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Funct Integr Genomics (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10142-024-01398-9"}], "href": "https://doi.org/10.1007/s10142-024-01398-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38980439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38980439"}]}]}]}