{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies on microRNAs have revealed that these small non-coding RNAs frequently display aberrant expression in neoplastic tissues, making them promising candidates for noninvasive cancer screening. In the context of colorectal cancer—a disease with high mortality—MIR1295B appears to be one such miRNA whose dysregulation may be integral to the disease’s molecular pathology. Given that colorectal cancer screening increasingly relies on the detection of molecular markers in accessible samples such as stool, the altered expression of MIR1295B could potentially serve as a biomarker for early detection and improved patient outcomes. This role aligns with the broader observation that many microRNAs are involved in modulating gene expression associated with tumor progression, suggesting that MIR1295B might contribute to either tumor suppression or oncogenic processes in colorectal neoplasia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Reza Ghanbari, Neda Mosakhani, Jahanbakhsh Asadi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of fecal miR-4478 and miR-1295b-3p in early-stage colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-140453"}], "href": "https://doi.org/10.3233/CBM-140453"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25519020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25519020"}]}]}]}