{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐1297 is emerging as a pleiotropic regulator in cancer biology with context‐dependent tumor suppressor functions. In several studies, its overexpression in lung adenocarcinoma, colorectal cancer, hepatocellular carcinoma, prostate cancer, gastric cancer, pancreatic adenocarcinoma, triple‐negative breast cancer, and glioma has been shown to inhibit cell proliferation, induce apoptosis, and reduce metastatic potential by directly targeting oncogenic drivers such as TRIB2, Cox‑2, HMGA2, AEG‑1, CCND2, CREB1, CDC6, and EZH2. These findings, along with an integrative review of miR‑1297’s dual roles, support its classification as a tumor suppressor in multiple malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nConversely, miR‑1297 can also function as an oncogene in certain tumor contexts. In laryngeal squamous cell carcinoma, testicular germ cell tumors, non‑small cell lung cancer, and melanoma, increased expression of miR‑1297 has been associated with enhanced cell viability, proliferation, and migration, largely through the inhibition of tumor suppressors such as PTEN. These data highlight the complex, context‐dependent behavior of miR‑1297 in modulating oncogenic pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its dichotomous roles in tumorigenesis, emerging evidence indicates that miR‑1297 is involved in diverse regulatory networks and may serve as a diagnostic or prognostic biomarker in both oncologic and non‑oncologic settings. Its altered serum levels have been linked to esophageal squamous cell cancer diagnosis and poor neurological outcome following aneurysmal subarachnoid hemorrhage, while deregulation of miR‑1297 has also been implicated in osteogenesis, diabetic nephropathy, and intestinal barrier injury. 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